Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
CTBP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CTBP1 Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Corepressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity. Homo- or heterodimer. Heterodimer with CTBP2. Interacts with PRDM16; the interaction represses white adipose tissue (WAT)- specific genes expression. Interacts with GLIS2, FOXP2, HDAC4, HDAC5, HDAC9 and ZNF217. Interacts with adenovirus E1A protein (via its C-terminus); the interaction disrupts the interaction of CTBP1 with RBBP8. Interacts with Epstein-Barr virus EBNA3 and EBNA6. Interacts with ELK3 (via its PXDLS motif). Interacts with RBBP8 (via its PXDLS motif); the interaction is disrupted by binding to adenovirus E1A. Interacts with FOXP1, HIPK2, PNN, NRIP1, MECOM, ZNF366, ZFHX1B and WIZ. Interaction with SATB1 (non-acetylated form); the interaction stabilizes its attachment to DNA and promotes transcription repression. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor; EC 1.1.1.-; Cell cycle regulation
Chromosomal Location of Human Ortholog: 4p16
Cellular Component: cytoplasm; nucleoplasm; nucleus; transcription factor complex; transcriptional repressor complex
Molecular Function: NAD binding; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; protein binding; protein C-terminus binding; protein domain specific binding; protein homodimerization activity; transcription factor activity; transcription factor binding
Biological Process: negative regulation of cell proliferation; negative regulation of histone acetylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of histone deacetylation; protein amino acid phosphorylation; regulation of cell cycle; transcription, DNA-dependent; viral genome replication; white fat cell differentiation
Disease: Wolf-hirschhorn Syndrome
Reference #:  Q13363 (UniProtKB)
Gene Symbols: CTBP1
Molecular weight: 47,535 Da
Basal Isoelectric point: 6.28  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CTBP1

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  InnateDB


Sites Implicated In
apoptosis, induced: S422‑p
transcription, altered: S158‑p
transcription, induced: S158‑p
enzymatic activity, inhibited: S158‑p
intracellular localization: S158‑p
protein degradation: S158‑p, S422‑p
ubiquitination: S158‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 Y76‑p EAVGALMyHTITLTR
1 1 S100‑p RIIVRIGsGFDNIDI
1 0 T144‑p LNLYRRAtWLHQALR
6 0 S158‑p REGTRVQsVEQIREV
0 2 K194‑ub QAVALRAkAFGFNVL
0 1 T264 QGAFLVNTARGGLVD
0 5 K273‑ub RGGLVDEkALAQALk
0 16 K280‑ub kALAQALkEGRIRGA
0 5 S300‑p ESEPFSFsQGPLKDA
3 1 S422‑p AHPPHAPsPGQTVkP
2 0 K428‑sm PsPGQTVkPEADRDH
  CTBP1 iso2  
Y65 EAVGALMYHTITLTR
S89 RIIVRIGSGFDNIDI
T133 LNLYRRATWLHQALR
S147‑p REGTRVQsVEQIREV
K183 QAVALRAKAFGFNVL
T253 QGAFLVNTARGGLVD
K262 RGGLVDEKALAQALK
K269 KALAQALKEGRIRGA
S289 ESEPFSFSQGPLKDA
S411 AHPPHAPSPGQTVKP
K417 PSPGQTVKPEADRDH
  mouse

 
Y76 EAVGALMYHTITLTR
S100 RIIVRIGSGFDNIDI
T144 LNLYRRTTWLHQALR
S158‑p REGTRVQsVEQIREV
K194 QAVALRAKAFGFNVL
T264‑p QGAFLVNtARGGLVD
K273‑ub RGGLVDEkALAQALk
K280‑ub kALAQALkEGRIRGA
S300 ESEPFSFSQGPLKDA
S423 AHPPHAPSPGQTVKP
K429 PSPGQTVKPEADRDH
  rat

 
Y65 EAVGALMYHTITLTR
S89 RIIVRIGSGFDNIDI
T133 LNLYRRTTWLHQALR
S147‑p REGTRVQsVEQIREV
K183 QAVALRAKAFGFNVL
T253 QGAFLVNTARGGLVD
K262 RGGLVDEKALAQALK
K269 KALAQALKEGRIRGA
S289 ESEPFSFSQGPLKDA
S412 AHPPHAPSPGQTVKP
K418 PSPGQTVKPEADRDH
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.