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Protein Page:
mGluR2 (mouse)

Overview
mGluR2 Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. Belongs to the G-protein coupled receptor 3 family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 3
Cellular Component: axon; integral to plasma membrane; intracellular; neuron projection; presynaptic membrane
Molecular Function: calcium channel regulator activity; group II metabotropic glutamate receptor activity
Biological Process: glutamate secretion; regulation of synaptic transmission, glutamatergic; synaptic transmission
Reference #:  Q14BI2 (UniProtKB)
Alt. Names/Synonyms: 4930441L02Rik; G protein coupled receptor, family C, group 1, member B; G protein-coupled receptor, family C, group 1, member B; glutamate receptor, metabotropic 2; Gprc1b; Grm2; Metabotropic glutamate receptor 2; mGluR2; mGluR7
Gene Symbols: Grm2
Molecular weight: 95,887 Da
Basal Isoelectric point: 8.44  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

mGluR2

Protein Structure Not Found.
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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 S109 ALDFVRASLSRGADG
0 1 S111 DFVRASLSRGADGSR
0 1 S246 EKVGRAMSRAAFEGV
0 1 T457 IGRYNIFTYLRAGNG
0 1 S501 TLPASRCSEPCLQNE
1 0 S675 AQRPRFISPASQVAI
0 1 Y734 SMLGSLAYNVLLIAL
0 1 Y745 LIALCTLYAFKTRKC
0 1 T749 CTLYAFKTRKCPENF
0 1 T832‑p VVSHRAPtsRFGSAA
0 1 S833‑p VSHRAPtsRFGSAAP
1 0 S843 GSAAPRASANLGQGS
0 3 S871‑p VVDSTTSsL______
  human

 
S109‑p ALDFVRAsLsRGADG
S111‑p DFVRAsLsRGADGSR
S246‑p EKVGRAMsRAAFEGV
T457‑p IGRYNIFtYLRAGSG
S501‑p PLPASRCsEPCLQNE
S675 AQRPRFISPASQVAI
Y734‑p SMLGSLAyNVLLIAL
Y745‑p LIALCTLyAFKtRKC
T749‑p CTLyAFKtRKCPENF
T832 VVSHRAPTSRFGSAA
S833 VSHRAPTSRFGSAAA
S843 GSAAARASSSLGQGS
S871 VVDSTTSSL______
  rat

 
S109 ALDFVRASLSRGADG
S111 DFVRASLSRGADGSR
S246 EKVGRAMSRAAFEGV
T457 IGRYNIFTYLRAGSG
S501 PLPASRCSEPCLQNE
S675‑p AQRPRFIsPASQVAI
Y734 SMLGSLAYNVLLIAL
Y745 LIALCTLYAFKTRKC
T749 CTLYAFKTRKCPENF
T832 VVSHRAPTSRFGSAA
S833 VSHRAPTSRFGSAAP
S843‑p GSAAPRAsANLGQGS
S871 VVDSTTSSL______
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