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Protein Page:
RAB3A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RAB3A Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal. Heterodimer with RIMS2. Part of a ternary complex involving PCLO and EPAC2. Interacts with RPH3A. Interacts with the exocyst complex through SEC15. Binds SYTL4, RIMS1 and RIMS2. Interacts with RAB3IP. Interacts with SGSM1 and SGSM3. Specifically expressed in brain. Belongs to the small GTPase superfamily. Rab family. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric; G protein, monomeric, Rab; G protein
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: acrosome; axon; cytosol; endosome; plasma membrane; protein complex; synaptic vesicle; terminal button
Molecular Function: ATPase activator activity; ATPase binding; GTP binding; GTPase activity; GTPase binding; myosin V binding; protein binding; protein C-terminus binding
Biological Process: axonogenesis; constitutive secretory pathway; glutamate secretion; intracellular protein transport; lung development; maintenance of presynaptic active zone structure; metabolic process; mitochondrion organization and biogenesis; neuromuscular synaptic transmission; neurotransmitter secretion; nucleocytoplasmic transport; positive regulation of ATPase activity; positive regulation of exocytosis; post-embryonic development; regulation of short-term neuronal synaptic plasticity; regulation of synaptic vesicle fusion to presynaptic membrane; respiratory system process; response to electrical stimulus; sensory perception of touch; small GTPase mediated signal transduction; synaptic vesicle exocytosis; synaptic vesicle maturation
Reference #:  P20336 (UniProtKB)
Alt. Names/Synonyms: RAB3A; RAB3A, member RAS oncogene family; RAS-associated protein RAB3A; Ras-related protein Rab-3A
Gene Symbols: RAB3A
Molecular weight: 24,984 Da
Basal Isoelectric point: 4.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RAB3A

Protein Structure Not Found.
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Download ChimeraX Script


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S7 _MASATDSRYGQKES
0 1 K12 TDSRYGQKESSDQNF
0 1 S14 SRYGQKESSDQNFDY
0 1 S15 RYGQKESSDQNFDYM
0 1 S31 KILIIGNSSVGKTSF
0 1 S32 ILIIGNSSVGKTSFL
0 1 S37 NSSVGKTSFLFRYAD
0 1 Y65‑p DFKVKTIyRNDKRIK
0 1 K72 yRNDKRIKLQIWDTA
0 1 K136 QVLLVGNKCDMEDER
0 1 K167 EFFEASAKDNINVKQ
0 3 K173 AKDNINVKQTFERLV
0 1 K186 LVDVICEKMSEsLDT
0 9 S188 DVICEKMSEsLDTAD
0 6 S190‑p ICEKMSEsLDTADPA
  mouse

 
S7‑p _MASATDsRYGQkEs
K12‑ub TDsRYGQkEssDQNF
S14‑p sRYGQkEssDQNFDY
S15‑p RYGQkEssDQNFDYM
S31‑p KILIIGNssVGKTsF
S32‑p ILIIGNssVGKTsFL
S37‑p NssVGKTsFLFRYAD
Y65 DFKVKTIYRNDKRIK
K72 YRNDKRIKLQIWDTA
K136‑ub QVLLVGNkCDMEDER
K167‑ub EFFEASAkDNINVkQ
K173‑ub AkDNINVkQTFERLV
K186‑ub LVDVICEkMsEsLDT
S188‑p DVICEkMsEsLDTAD
S190‑p ICEkMsEsLDTADPA
  rat

 
S7 _MASATDSRYGQKES
K12 TDSRYGQKESSDQNF
S14 SRYGQKESSDQNFDY
S15 RYGQKESSDQNFDYM
S31 KILIIGNSSVGKTSF
S32 ILIIGNSSVGKTSFL
S37 NSSVGKTSFLFRYAD
Y65 DFKVKTIYRNDKRIk
K72‑ub YRNDKRIkLQIWDTA
K136 QVLLVGNKCDMEDER
K167 EFFEASAKDNINVkQ
K173‑ub AKDNINVkQTFERLV
K186 LVDVICEKMsEsLDT
S188‑p DVICEKMsEsLDTAD
S190‑p ICEKMsEsLDTADPA
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