Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Binds RIPK1 and FAIM2. Interacts with BRE and FEM1B. Interacts with FADD. Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Receptor, cytokine; Membrane protein, integral; Cell surface; Apoptosis
Cellular Component: apical plasma membrane; CD95 death-inducing signaling complex; cell soma; cell surface; cytoplasm; cytosol; external side of plasma membrane; extracellular space; integral to plasma membrane; lipid raft; neuron projection; nucleus; perinuclear region of cytoplasm; plasma membrane; sarcolemma; secretory granule
Molecular Function: identical protein binding; kinase binding; protease binding; protein binding; protein complex binding; receptor activity; signal transducer activity; tumor necrosis factor receptor activity
Biological Process: activated T cell apoptosis; aging; apoptosis; B cell mediated immunity; brain development; caspase activation; chordate embryonic development; circadian rhythm; dendrite regeneration; immune response; immunoglobulin production; induction of apoptosis via death domain receptors; inflammatory cell apoptosis; inflammatory response; maternal process involved in pregnancy; negative regulation of apoptosis; negative regulation of B cell activation; negative thymic T cell selection; ovarian follicle atresia; ovulation cycle; positive regulation of apoptosis; positive regulation of MAPKKK cascade; positive regulation of protein homooligomerization; protein complex assembly; protein homooligomerization; regulation of apoptosis; regulation of caspase activity; regulation of cell proliferation; regulation of gene expression; regulation of lymphocyte differentiation; regulation of myeloid cell differentiation; renal system process; response to cycloheximide; response to drug; response to glucocorticoid stimulus; response to lipopolysaccharide; response to peptide hormone stimulus; response to toxin; signal transduction; spermatogenesis; spleen development; telencephalon development; transformed cell apoptosis; tumor necrosis factor-mediated signaling pathway
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.