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Protein Page:
MARK3 (human)

Overview
MARK3 an ubiquitous serine/threonine kinase of the CAMKL family. Phosphorylates Cdc25C on serine 216 and promotes 14-3-3 protein binding. A positive regulator of Wnt signalling. Ubiquitously expressed in human tissues and cell lines. Seven alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMKL family; EC 2.7.11.1; Kinase, protein; MARK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 14q32.32
Cellular Component: cytosol; plasma membrane
Molecular Function: protein binding; protein serine/threonine kinase activity
Biological Process: MAPKKK cascade
Reference #:  P27448 (UniProtKB)
Alt. Names/Synonyms: C-TAK1; Cdc25C-associated protein kinase 1; CTAK1; ELKL motif kinase 2; EMK-2; EMK2; KP78; MAP/microtubule affinity-regulating kinase 3; MARK3; PAR1A; Protein kinase STK10; Ser/Thr protein kinase PAR-1; Serine/threonine-protein kinase p78
Gene Symbols: MARK3
Molecular weight: 84,489 Da
Basal Isoelectric point: 9.59  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MARK3

Protein Structure Not Found.
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