a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5'- CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor
Molecular Function: bHLH transcription factor binding; DNA binding; mitogen-activated protein kinase kinase kinase binding; protein binding; protein heterodimerization activity; protein homodimerization activity; transcription coactivator activity; transcription factor activity; transcription factor binding
Biological Process: immunoglobulin V(D)J recombination; negative regulation of transcription from RNA polymerase II promoter; positive regulation of muscle cell differentiation; positive regulation of neuron differentiation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent