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Protein Page:
MEK2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MEK2 a dual-specificity protein kinase of the STE7 kinase family. Phosphorylated and activated by Raf and Mos kinases. Phosphorylates a Thr and a Tyr residue in a Thr-Glu-Tyr sequence located in the activation loop of ERK2 and ERK3. A component of MAP kinase signal transduction pathways involved in mitogen growth factor signal transduction. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, dual-specificity (non-receptor); EC 2.7.12.2; Protein kinase, STE; Kinase, protein; STE group; STE7 family
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: cell cortex; cytoplasm; cytosol; early endosome; endoplasmic reticulum; extracellular region; focal adhesion; Golgi apparatus; intercellular junction; internal side of plasma membrane; late endosome; microtubule; mitochondrion; nucleus; perinuclear region of cytoplasm; peroxisomal membrane
Molecular Function: ATP binding; MAP kinase kinase activity; metal ion binding; PDZ domain binding; protein binding; protein complex scaffold; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein-tyrosine kinase activity; receptor signaling protein serine/threonine kinase activity
Biological Process: activation of MAPK activity; heart development; MAPKKK cascade; peptidyl-tyrosine phosphorylation; positive regulation of axonogenesis; regulation of axon regeneration; regulation of stress-activated MAPK cascade; thymus development; thyroid gland development
Disease: Cardiofaciocutaneous Syndrome 4
Reference #:  P36507 (UniProtKB)
Gene Symbols: MAP2K2
Molecular weight: 44,424 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Angiogenesis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Insulin Receptor Signaling  |  T Cell Receptor Signaling  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MEK2

Protein Structure Not Found.
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Sites Implicated In
enzymatic activity, induced: S222‑p, S226‑p
enzymatic activity, inhibited: S216‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 T13‑ac KPVLPALtINPTIAE
0 12 S23‑p PTIAEGPsPTsEGAs
0 1 T25 IAEGPsPTsEGAsEA
0 3 S26‑p AEGPsPTsEGAsEAN
0 2 S30‑p sPTsEGAsEANLVDL
0 1 K40‑ub NLVDLQKkLEELELD
0 1 K51‑ub LELDEQQkKRLEAFL
0 1 K61‑ub LEAFLTQkAkVGELk
0 2 K63‑ub AFLTQkAkVGELkDD
0 2 K68‑ub kAkVGELkDDDFERI
0 1 S76 DDDFERISELGAGNG
0 2 K88‑ub GNGGVVTkVQHRPsG
0 1 S94‑p TkVQHRPsGLIMARk
0 10 K101‑ub sGLIMARkLIHLEIk
0 13 K108‑ub kLIHLEIkPAIRNQI
0 27 K196‑ub QIMHRDVkPSNILVN
0 11 K209‑ub VNSRGEIkLCDFGVs
3 4 S216‑p kLCDFGVsGQLIDsM
46 82 S222‑p VsGQLIDsMANsFVG
11 1 S222‑ac VsGQLIDsMANsFVG
49 211 S226‑p LIDsMANsFVGTRSY
2 0 S226‑ac LIDsMANsFVGTRSY
0 1 D285‑ca IFGRPVVdGEEGEPH
0 8 S293‑p GEEGEPHsIsPRPRP
0 20 S295‑p EGEPHsIsPRPRPPG
1 7 S306‑p RPPGRPVsGHGMDsR
0 2 S312‑p VsGHGMDsRPAMAIF
0 1 K361 PAERADLKMLTNHTF
0 1 S372‑p NHTFIKRsEVEEVDF
0 8 G393 TLRLNQPGtPtRtAV
1 105 T394‑p LRLNQPGtPtRtAV_
2 22 T396‑p LNQPGtPtRtAV___
1 0 T398‑p QPGtPtRtAV_____
3958 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Biotinylated)
9121 : Phospho-MEK1/2 (Ser217/221) Antibody
9154 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb
2338 : Phospho-MEK1/2 (Ser221) (166F8) Rabbit mAb
3958 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Biotinylated)
9121 : Phospho-MEK1/2 (Ser217/221) Antibody
9154 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb
16211 : Phospho-MEK1/2 (Ser221) (166F8) Rabbit mAb (PE Conjugate)
  mouse

 
T13 KPVLPALTINPTIAE
S23‑p PTIAEGPsPtsEGAs
T25‑p IAEGPsPtsEGAsEA
S26‑p AEGPsPtsEGAsEAN
S30‑p sPtsEGAsEANLVDL
K40 NLVDLQKKLEELDLD
R51 LDLDEQQRKRLEAFL
K61 LEAFLTQKAKVGELK
K63 AFLTQKAKVGELKDD
K68 KAKVGELKDDDFERI
S76‑p DDDFERIsELGAGNG
K88‑ub GNGGVVTkARHRPSG
S94 TkARHRPSGLIMARK
K101 SGLIMARKLIHLEIK
K108 KLIHLEIKPAVRNQI
K196‑ub QIMHRDVkPSNILVN
K209 VNSRGEIKLCDFGVs
S216‑p KLCDFGVsGQLIDsM
S222‑p VsGQLIDsMANsFVG
S222‑ac VsGQLIDsMANsFVG
S226‑p LIDsMANsFVGTRSY
S226‑ac LIDsMANsFVGTRSY
D285 SFGRPVVDGADGEPH
S293‑p GADGEPHsVsPRPRP
S295‑p DGEPHsVsPRPRPPG
S306‑p RPPGRPIsVGHGMDS
S313 sVGHGMDSRPAMAIF
K362‑ub PAERADLkLLMNHAF
S373 NHAFIKRSEGEEVDF
S394‑p TLRLKQPstPtRTAV
T395‑p LRLKQPstPtRTAV_
T397‑p LKQPstPtRTAV___
T399 QPstPtRTAV_____
3958 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Biotinylated)
9121 : Phospho-MEK1/2 (Ser217/221) Antibody
9154 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb
2338 : Phospho-MEK1/2 (Ser221) (166F8) Rabbit mAb
3958 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Biotinylated)
9121 : Phospho-MEK1/2 (Ser217/221) Antibody
9154 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb
16211 : Phospho-MEK1/2 (Ser221) (166F8) Rabbit mAb (PE Conjugate)
  rat

 
T13 KPVLPALTINPTIAE
S23 PTIAEGPSPTSEGAS
T25 IAEGPSPTSEGASEA
S26 AEGPSPTSEGASEAH
S30 SPTSEGASEAHLVDL
K40 HLVDLQKKLEELDLD
R51 LDLDEQQRKRLEAFL
K61 LEAFLTQKAKVGELK
K63 AFLTQKAKVGELKDD
K68 KAKVGELKDDDFERI
S76 DDDFERISELGAGNG
K88 GNGGVVTKARHRPSG
S94 TKARHRPSGLIMARK
K101 SGLIMARKLIHLEIK
K108 KLIHLEIKPAVRNQI
K196‑ub QIMHRDVkPSNILVN
K209 VNSRGEIKLCDFGVS
S216 KLCDFGVSGQLIDsM
S222‑p VSGQLIDsMANsFVG
S222‑ac VSGQLIDsMANsFVG
S226‑p LIDsMANsFVGTRSY
S226 LIDsMANSFVGTRSY
D285 SFGRPVVDGADGEPH
S293 GADGEPHSVsPRPRP
S295‑p DGEPHSVsPRPRPPG
S306 RPPGRPISGHGMDSR
S312 ISGHGMDSRPAMAIF
K361 PAERADLKLLTNHAF
S372 NHAFIKRSEGEDVDF
S393‑p TLRLKQPstPTRTAV
T394‑p LRLKQPstPTRTAV_
T396 LKQPstPTRTAV___
T398 QPstPTRTAV_____
3958 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Biotinylated)
9121 : Phospho-MEK1/2 (Ser217/221) Antibody
9154 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb
2338 : Phospho-MEK1/2 (Ser221) (166F8) Rabbit mAb
3958 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Biotinylated)
9121 : Phospho-MEK1/2 (Ser217/221) Antibody
9154 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb
16211 : Phospho-MEK1/2 (Ser221) (166F8) Rabbit mAb (PE Conjugate)
  chicken

 
T13 KPVLPALTITPSPAE
G23 PSPAEGPGPGGSAEA
G25 PAEGPGPGGSAEANL
- gap
A28 GPGPGGSAEANLVDL
K38 NLVDLQKKLEELELD
K49 LELDEQQKKRLEAFL
K59 LEAFLTQKAKVGELK
K61 AFLTQKAKVGELKDD
K66 KAKVGELKDDDFERI
S74 DDDFERISELGAGNG
K86 GNGGVVTKVQHKPSG
S92 TKVQHKPSGLIMARK
K99 SGLIMARKLIHLEIK
K106 KLIHLEIKPAIRNQI
K194 QIMHRDVKPSNILVN
K207 VNSRGEIKLCDFGVS
S214 KLCDFGVSGQLIDSM
S220 VSGQLIDSMANSFVG
S220 VSGQLIDSMANSFVG
S224 LIDSMANSFVGTRSY
S224 LIDSMANSFVGTRSY
D283 IFGRPVVDGAEGESH
S291 GAEGESHSVSPWARP
S293 EGESHSVSPWARPPG
S304 RPPGRPISGHGMDSR
S310 ISGHGMDSRPAMAIF
K359 PAERADLKMLMNHTF
S370 NHTFIKRSEVEEVDF
S391 TLRLNQPSTPTRAAV
T392 LRLNQPSTPTRAAV_
T394 LNQPSTPTRAAV___
A396 QPSTPTRAAV_____
3958 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Biotinylated)
9121 : Phospho-MEK1/2 (Ser217/221) Antibody
9154 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb
3958 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Biotinylated)
9121 : Phospho-MEK1/2 (Ser217/221) Antibody
9154 : Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb
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