a dual-specificity protein kinase of the STE7 kinase family. Phosphorylated and activated by Raf and Mos kinases. Phosphorylates a Thr and a Tyr residue in a Thr-Glu-Tyr sequence located in the activation loop of ERK2 and ERK3. A component of MAP kinase signal transduction pathways involved in mitogen growth factor signal transduction. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, STE; Kinase, protein; Protein kinase, dual-specificity (non-receptor); EC 18.104.22.168; STE group; STE7 family
Cellular Component: cell cortex; cytoplasm; cytosol; early endosome; endoplasmic reticulum; extracellular region; focal adhesion; Golgi apparatus; intercellular junction; internal side of plasma membrane; late endosome; microtubule; mitochondrion; nucleus; perinuclear region of cytoplasm; peroxisomal membrane
Molecular Function: ATP binding; MAP kinase kinase activity; metal ion binding; PDZ domain binding; protein binding; protein complex scaffold; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein-tyrosine kinase activity
Biological Process: activation of MAPK activity; activation of MAPKK activity; axon guidance; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; heart development; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; nerve growth factor receptor signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of axonogenesis; Ras protein signal transduction; regulation of apoptosis; regulation of axon regeneration; regulation of mitotic cell cycle; regulation of stress-activated MAPK cascade; small GTPase mediated signal transduction; stress-activated protein kinase signaling pathway; thymus development; thyroid gland development; vascular endothelial growth factor receptor signaling pathway
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.