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Protein Page:
MAPKAPK3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MAPKAPK3 a member of the MAPKAPK family of protein kinases. Activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); CAMK group; MAPKAPK family; MAPKAPK subfamily
Chromosomal Location of Human Ortholog: 3p21.3
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; MAP kinase kinase activity; protein binding; protein serine/threonine kinase activity
Biological Process: activation of MAPK activity; cell surface receptor linked signal transduction; MAPKKK cascade; peptidyl-serine phosphorylation; protein amino acid autophosphorylation; Ras protein signal transduction; response to cytokine stimulus; response to lipopolysaccharide; response to stress; signal transduction; toll-like receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway
Reference #:  Q16644 (UniProtKB)
Gene Symbols: MAPKAPK3
Molecular weight: 42,987 Da
Basal Isoelectric point: 6.87  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics  |  Regulation of P38 MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MAPKAPK3

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 T5‑p ___MDGEtAEEQGGP
0 1 Y37 GRREPKKYAVTDDyQ
0 12 Y43‑p KYAVTDDyQLSKQVL
0 93 Y76‑p KCALKLLyDSPKARQ
0 2 K177‑ac ENLLYTSkEkDAVLK
0 4 K179‑ac LLYTSkEkDAVLKLT
2 39 T201‑p TTQNALQtPCytPyy
0 23 Y204‑p NALQtPCytPyyVAP
0 11 T205‑p ALQtPCytPyyVAPE
0 9 Y207‑p QtPCytPyyVAPEVL
0 6 Y208‑p tPCytPyyVAPEVLG
0 1 S244‑p CGFPPFYsNtGQAIs
0 1 T246‑p FPPFYsNtGQAIsPG
2 1 S251‑p sNtGQAIsPGMKRRI
0 1 K286 QLIRLLLKTDPTERL
0 1 S307‑p NHPWINQsMVVPQtP
2 21 T313‑p QsMVVPQtPLHtARV
1 16 T317‑p VPQtPLHtARVLQED
0 1 K332‑ac KDHWDEVkEEMTSAL
0 47 Y346‑p LATMRVDyDQVKIKD
0 2 S372‑p RRKKQAGsssAsQGC
0 2 S373‑p RKKQAGsssAsQGCN
0 2 S374‑p KKQAGsssAsQGCNN
0 2 S376‑p QAGsssAsQGCNNQ_
  mouse

 
T5 ___MDGETAGEKGSL
Y39‑p VRREPKKyAVTDDyQ
Y45‑p KyAVTDDyQLSKQVL
Y78‑p KCALKLLyDSPKARQ
K179‑ac ENLLYTSkEKDAVLK
K181 LLYTSkEKDAVLKLT
T203‑p TTQNALQtPCYTPYY
Y206 NALQtPCYTPYYVAP
T207 ALQtPCYTPYYVAPE
Y209 QtPCYTPYYVAPEVL
Y210 tPCYTPYYVAPEVLG
S246 CGFPPFYSNTGQAIs
T248 FPPFYSNTGQAIsPG
S253‑p SNTGQAIsPGMKRRI
K288 QLIRLLLKTDPTERL
S309 NHPWINQSMVVPQtP
T315‑p QSMVVPQtPLYTARV
T319 VPQtPLYTARVLQED
K334 KDHWDDVKEEMTSAL
Y348 LATMRVDYDQVKIKD
S374 RRKKQAGSSSASQGC
S375 RKKQAGSSSASQGCN
S376 KKQAGSSSASQGCNN
S378 QAGSSSASQGCNNQ_
  rat

 
T5 ___MDGETAGEKGSL
Y39 VRREPKKYAVTDDYQ
Y45 KYAVTDDYQLSKQVL
Y78 KCALKLLYDSPKARQ
K179 ENLLYTSKEKDAVLK
K181 LLYTSKEKDAVLKLT
T203 TTQNALQTPCYTPYY
Y206 NALQTPCYTPYYVAP
T207 ALQTPCYTPYYVAPE
Y209 QTPCYTPYYVAPEVL
Y210 TPCYTPYYVAPEVLG
S246 CGFPPFYSNTGQAIS
T248 FPPFYSNTGQAISPG
S253 SNTGQAISPGMKRRI
K288‑ac QLIRLLLkTDPTERL
S309 NHPWINQSMEVPQTP
T315 QSMEVPQTPLHTARV
T319 VPQTPLHTARVLEED
K334 KDHWDDVKEEMTSAL
Y348 LATMRVDYDQVKIKD
S374 RRKKQGGSSSASPGC
S375 RKKQGGSSSASPGCN
S376 KKQGGSSSASPGCNN
S378 QGGSSSASPGCNNQ_
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