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Protein Page:
MAPKAPK3 (human)

Overview
MAPKAPK3 a member of the MAPKAPK family of protein kinases. Activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Note: This description may include information from UniProtKB.
Protein type: CAMK group; EC 2.7.11.1; Kinase, protein; MAPKAPK family; MAPKAPK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 3p21.3
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; MAP kinase kinase activity; protein binding; protein serine/threonine kinase activity
Biological Process: activation of MAPK activity; cell surface receptor linked signal transduction; peptidyl-serine phosphorylation; protein amino acid autophosphorylation; Ras protein signal transduction; response to cytokine stimulus; response to lipopolysaccharide; response to stress; signal transduction; toll-like receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway
Reference #:  Q16644 (UniProtKB)
Alt. Names/Synonyms: 3pK; Chromosome 3p kinase; MAP kinase-activated protein kinase 3; MAPK-activated protein kinase 3; MAPK3; MAPKAP kinase 3; MAPKAP3; MAPKAPK-3; MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3
Gene Symbols: MAPKAPK3
Molecular weight: 42,987 Da
Basal Isoelectric point: 6.87  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics  |  Regulation of P38 MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MAPKAPK3

Protein Structure Not Found.
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