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Protein Page:
MEIS2 (human)

Overview
MEIS2 a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 15q14
Cellular Component: nucleus; perinuclear region of cytoplasm
Molecular Function: protein binding; sequence-specific DNA binding; transcription cofactor activity; transcription corepressor activity; transcription factor activity; transcription factor binding
Biological Process: eye development; negative regulation of myeloid cell differentiation; negative regulation of transcription from RNA polymerase II promoter; pancreas development; positive regulation of transcription from RNA polymerase II promoter; response to mechanical stimulus; transcription from RNA polymerase II promoter; visual learning
Reference #:  O14770 (UniProtKB)
Gene Symbols: MEIS2
Molecular weight: 51,790 Da
Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MEIS2

Protein Structure Not Found.
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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 6 S198‑p ERDGSSKsDHEELSG
0 1 S261 GLDNSVASPGTGDDD
0 1 T264 NSVASPGTGDDDDPD
  mouse

 
S198‑p ERDGSSKsDHEELSG
S261‑p GLDNSVAsPGtGDDD
T264‑p NSVAsPGtGDDDDPD
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