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Protein Page:
BTRC (human)

Overview
BTRC a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Regulates the stability of CTNNB1 and participates in Wnt signaling. Interacts directly with SKP1 in the SCF complex. Interacts specifically with phosphorylated CTNNB1 and NFKBIA, ubiquitination substrates. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 10q24.32
Cellular Component: cytosol; nucleoplasm; SCF ubiquitin ligase complex
Molecular Function: beta-catenin binding; ligase activity; protein binding; protein dimerization activity; protein phosphorylated amino acid binding; ubiquitin-protein ligase activity
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; circadian rhythm; G2/M transition of mitotic cell cycle; innate immune response; mammary gland epithelial cell proliferation; mitotic cell cycle; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; negative regulation of smoothened signaling pathway; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; positive regulation of circadian rhythm; positive regulation of proteolysis; positive regulation of transcription, DNA-dependent; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid dephosphorylation; protein destabilization; protein polyubiquitination; protein ubiquitination; regulation of circadian rhythm; regulation of I-kappaB kinase/NF-kappaB cascade; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; signal transduction; stimulatory C-type lectin receptor signaling pathway; stress-activated MAPK cascade; T cell receptor signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; ubiquitin-dependent protein catabolic process; viral reproduction; Wnt receptor signaling pathway
Reference #:  Q9Y297 (UniProtKB)
Alt. Names/Synonyms: beta-transducin repeat containing; BETA-TRCP; beta-TrCP1; betaTrCP; BTRC; BTRCP; bTrCP1; E3RSIkappaB; F-box and WD repeats protein beta-TrCP; F-box/WD repeat-containing protein 1A; FBW1A; FBXW1; FBXW1A; FWD1; MGC4643; pIkappaBalpha-E3 receptor subunit
Gene Symbols: BTRC
Molecular weight: 68,867 Da
Basal Isoelectric point: 8.3  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling  |  NF-kB Signaling  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BTRC

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 S127‑p VPKQRKLsASYEKEK
0 1 S129 KQRKLsASYEKEKEL
0 1 S555‑p LRTLVEHsGRVFRLQ
0 42 Y600‑p PRSPSRTyTyISR__
0 35 Y602‑p SPSRTyTyISR____
  mouse

► Hide Isoforms
 
S127‑p VPKQRKLsAsYEKEK
S129‑p KQRKLsAsYEKEKEL
S555 LRTLVEHSGRVFRLQ
Y600‑p PRSPSRTyTYISR__
Y602 SPSRTyTYISR____
  BTRC iso2  
S91 VPKQRKLSASYEKEK
S93 KQRKLSASYEKEKEL
S519 LRTLVEHSGRVFRLQ
Y564 PRSPSRTYTYISR__
Y566 SPSRTYTYISR____
  rat

 
S28 VPKQRKLSASYEKEK
S30 KQRKLSASYEKEKEL
S456 LRTLVEHSGRVFRLQ
Y501‑p PRSPSRTyTYISR__
Y503 SPSRTyTYISR____
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