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Protein Page:
BTRC (human)

BTRC a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Regulates the stability of CTNNB1 and participates in Wnt signaling. Interacts directly with SKP1 in the SCF complex. Interacts specifically with phosphorylated CTNNB1 and NFKBIA, ubiquitination substrates. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 10q24.32
Cellular Component: cytosol; nucleoplasm; SCF ubiquitin ligase complex
Molecular Function: beta-catenin binding; protein binding; ubiquitin-protein ligase activity
Biological Process: G2/M transition of mitotic cell cycle; negative regulation of smoothened signaling pathway; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; positive regulation of circadian rhythm; positive regulation of proteolysis; positive regulation of transcription, DNA-dependent; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid dephosphorylation; protein destabilization; protein polyubiquitination; protein ubiquitination; regulation of circadian rhythm; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; signal transduction; stimulatory C-type lectin receptor signaling pathway; stress-activated MAPK cascade; T cell receptor signaling pathway; ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway
Reference #:  Q9Y297 (UniProtKB)
Alt. Names/Synonyms: beta-transducin repeat containing; BETA-TRCP; beta-TrCP1; betaTrCP; BTRC; BTRCP; bTrCP1; E3RSIkappaB; F-box and WD repeats protein beta-TrCP; F-box/WD repeat-containing protein 1A; FBW1A; FBXW1; FBXW1A; FWD1; MGC4643; pIkappaBalpha-E3 receptor subunit
Gene Symbols: BTRC
Molecular weight: 68,867 Da
Basal Isoelectric point: 8.3  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling  |  NF-kB Signaling  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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