an oncogenic Ser/Thr kinase of the STE group. Activates IkappaB kinases, thus inducing the nuclear translocation of NF-kappaB. Promotes the production of TNF-alpha and IL-2 during T lymphocyte activation. Interacts with NFkB-p105. Overexpressed and amplified in breast tumors. Viral insertions induce rat lymphomas and mouse mammary carcinomas. Isolated as a transforming factor in two cell lines. Mediates LPS activation of macrophages. 2 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB.
Protein type: EC 220.127.116.11; Kinase, protein; Oncoprotein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE-Unique family
Molecular Function: MAP kinase kinase kinase activity; protein binding; protein serine/threonine kinase activity
Biological Process: activation of protein kinase activity; protein amino acid phosphorylation; regulation of apoptosis; regulation of mitotic cell cycle; stress-activated MAPK cascade; stress-activated protein kinase signaling pathway; T cell costimulation