an AGC kinase of the NDR family of kinases. A tumor suppressor of the LATS family. Plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Inhibits cell growth at the G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Interacts with and is phosphorylated by STK6. Ectopic expression induces apoptosis in lung cancer cell lines. Negatively regulates androgen receptor, and is downregulated in prostate cancer Note: This description may include information from UniProtKB.
Protein type: AGC group; EC 18.104.22.168; Kinase, protein; NDR family; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor
Cellular Component: cytosol; microtubule organizing center; nucleus; spindle pole
Molecular Function: ATP binding; protein binding; protein serine/threonine kinase activity
Biological Process: G1/S transition of mitotic cell cycle; hormone-mediated signaling; negative regulation of cyclin-dependent protein kinase activity; peptidyl-serine phosphorylation; positive regulation of apoptosis; protein amino acid phosphorylation; regulation of organ growth