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Protein Page:
GRK6 (human)

GRK6 Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamin receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). Widely expressed. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; GRK family; GRK subfamily; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 5q35
Cellular Component: membrane; plasma membrane
Molecular Function: beta-adrenergic receptor kinase activity
Biological Process: regulation of G-protein coupled receptor protein signaling pathway
Reference #:  P43250 (UniProtKB)
Alt. Names/Synonyms: FLJ32135; G protein-coupled receptor kinase 6; G protein-coupled receptor kinase GRK6; GPRK6; GRK6
Gene Symbols: GRK6
Molecular weight: 65,991 Da
Basal Isoelectric point: 8.32  Predict pI for various phosphorylation states
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