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Protein Page:
PSMB6 (human)

PSMB6 The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the peptidyl glutamyl-like activity. May catalyze basal processing of intracellular antigens. Belongs to the peptidase T1B family. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Proteasome complex
Chromosomal Location of Human Ortholog: 17p13
Cellular Component: cell-cell adherens junction; cytoplasm; cytosol; Golgi apparatus; nucleoplasm; nucleus; proteasome complex; proteasome core complex
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; MAPKKK cascade; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of amino acid metabolic process; regulation of mRNA stability; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway
Reference #:  P28072 (UniProtKB)
Alt. Names/Synonyms: DELTA; LMPY; Macropain delta chain; MGC5169; Multicatalytic endopeptidase complex delta chain; proteasome (prosome, macropain) subunit, beta type, 6; proteasome catalytic subunit 1; Proteasome delta chain; proteasome subunit beta 6; Proteasome subunit beta type-6; proteasome subunit delta; Proteasome subunit Y; PSB6; PSMB6; PSY large multifunctional protease Y; Y
Gene Symbols: PSMB6
Molecular weight: 25,358 Da
Basal Isoelectric point: 4.8  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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