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Protein Page:
PSMB6 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PSMB6 The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the peptidyl glutamyl-like activity. May catalyze basal processing of intracellular antigens. Belongs to the peptidase T1B family. Note: This description may include information from UniProtKB.
Protein type: Proteasome complex; EC 3.4.25.1; Protease
Chromosomal Location of Human Ortholog: 17p13
Cellular Component: cytoplasm; cytosol; Golgi apparatus; nucleoplasm; nucleus; proteasome complex; proteasome core complex
Molecular Function: endopeptidase activity; threonine endopeptidase activity
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; MAPKKK cascade; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of amino acid metabolic process; regulation of mRNA stability; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; viral reproduction; Wnt receptor signaling pathway, planar cell polarity pathway
Reference #:  P28072 (UniProtKB)
Gene Symbols: PSMB6
Molecular weight: 25,358 Da
Basal Isoelectric point: 4.8  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PSMB6

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 P13 LAARGAGPAPAWGPE
0 34 T23‑p AWGPEAFtPDWESRE
0 1 T54‑p VLGADSRtTtGsyIA
0 1 T56‑p GADSRtTtGsyIANR
0 2 S58‑p DSRtTtGsyIANRVT
0 46 Y59‑p SRtTtGsyIANRVTD
0 13 K67‑ub IANRVTDkLtPIHDR
0 3 T69‑p NRVTDkLtPIHDRIF
0 2 K118‑ac HTAASLFkEMCYRYR
1 1 S158‑p GGMMVRQsFAIGGSG
0 1 Y177‑p YGYVDATyREGMTkE
0 1 K183‑ub TyREGMTkEECLQFt
0 1 T190‑p kEECLQFtANALALA
0 1 S203‑p LAMERDGssGGVIRL
0 1 S204‑p AMERDGssGGVIRLA
0 3 S216‑p RLAAIAEsGVERQVL
0 2 K230‑ub LLGDQIPkFAVATLP
  mouse

 
S12‑p LAVRRAGsAPAFGPE
T22‑p AFGPEALtPDWENRE
T53 VLGADSRTTTGSyIA
T55 GADSRTTTGSyIANR
S57 DSRTTTGSyIANRVT
Y58‑p SRTTTGSyIANRVTD
K66 IANRVTDKLTPIHDH
T68 NRVTDKLTPIHDHIF
K117 HTAASLFKEMCYRYR
S157‑p GGMMVRQsFAIGGSG
Y176 YGYVDATYREGMTKD
K182 TYREGMTKDECLQFT
T189 KDECLQFTANALALA
S202 LAMERDGSSGGVIRL
S203 AMERDGSSGGVIRLA
S215 RLAAIQESGVERQVL
K229 LLGDQIPKFTIATLP
  rat

 
S12 LAVRGAVSAPAFGPE
T22 AFGPEALTPDWENRE
T53 VLGADSRTTTGSYIA
T55 GADSRTTTGSYIANR
S57 DSRTTTGSYIANRVT
Y58 SRTTTGSYIANRVTD
K66 IANRVTDKLTPIHDH
T68 NRVTDKLTPIHDHIF
K117 HTAASLFKEMCYRYR
S157 GGMMVRQSFAIGGSG
Y176 YGYVDATYREGMTKD
K182 TYREGMTKDECLQFT
T189 KDECLQFTANALALA
S202 LAMERDGSSGGVIRL
S203 AMERDGSSGGVIRLA
S215 RLAAIQQSGVERQVL
K229 LLGDQIPKVTISTLP
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