DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Belongs to the HMGB family. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; DNA-binding
Cellular Component: cell; condensed chromosome; cytoplasm; extracellular space; nuclear chromatin; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; protein complex
Molecular Function: chemoattractant activity; damaged DNA binding; DNA bending activity; DNA binding; double-stranded DNA binding; drug binding; four-way junction DNA binding; protein binding; protein domain specific binding; RAGE receptor binding; single-stranded DNA binding; transcription factor activity; transcription factor binding
Biological Process: apoptosis; cell structure disassembly during apoptosis; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; DNA fragmentation during apoptosis; DNA geometric change; DNA ligation during DNA repair; DNA topological change; establishment and/or maintenance of chromatin architecture; inflammatory response to antigenic stimulus; innate immune response; male gonad development; negative regulation of transcription, DNA-dependent; nucleosome assembly; positive chemotaxis; positive regulation of DNA binding; positive regulation of endothelial cell proliferation; positive regulation of erythrocyte differentiation; positive regulation of innate immune response; positive regulation of interferon-beta production; positive regulation of megakaryocyte differentiation; positive regulation of nuclease activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; programmed cell death; regulation of neurogenesis; regulation of transcription from RNA polymerase II promoter; response to drug; response to lipopolysaccharide; response to steroid hormone stimulus; spermatid nuclear differentiation; transcription, DNA-dependent; V(D)J recombination
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.