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Protein Page:
DYRK2 (human)

Overview
DYRK2 a dual-specificity protein kinase of the DYRK family. Localizes in the cytoplasm. Phosphorylates the translation initiation factor eIF2B at Ser539, priming it for phosphorylation by glycogen synthase kinase-3. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, CMGC; EC 2.7.12.1; Kinase, protein; Protein kinase, dual-specificity (non-receptor); CMGC group; DYRK family; Dyrk2 subfamily
Chromosomal Location of Human Ortholog: 12q15
Cellular Component: cytoplasm; nucleoplasm; nucleus; ubiquitin ligase complex
Molecular Function: ATP binding; magnesium ion binding; manganese ion binding; protein binding; protein serine/threonine kinase activity; protein-tyrosine kinase activity; ubiquitin binding
Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; negative regulation of NFAT protein import into nucleus; positive regulation of glycogen biosynthetic process; protein amino acid phosphorylation; response to DNA damage stimulus; smoothened signaling pathway
Reference #:  Q92630 (UniProtKB)
Alt. Names/Synonyms: Dual specificity tyrosine-phosphorylation-regulated kinase 2; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2; DYRK2; FLJ21217; FLJ21365
Gene Symbols: DYRK2
Molecular weight: 66,652 Da
Basal Isoelectric point: 9.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DYRK2

Protein Structure Not Found.
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Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
apoptosis, altered: S442‑p
enzymatic activity, induced: S442‑p
intracellular localization: T106‑p
molecular association, regulation: T106‑p
protein stabilization: T106‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 10 S30‑p AVRQLQAsPGLGAGA
0 6 S48‑p GVGTGPPsPIALPPL
1 0 T106‑p NKRTVLTtQPNGLTT
0 1 S142‑p GSSTSLKsMEGMGKV
0 2 Y380‑p CYEHQRVytyIQSRF
1 12 T381‑p YEHQRVytyIQSRFY
1 1654 Y382‑p EHQRVytyIQSRFYR
0 2 Y388 tyIQSRFYRAPEVIL
1 0 S442‑p IELLGMPsQKLLDAs
1 0 S449‑p sQKLLDAsKRAKNFV
0 1 Y464‑p SSKGYPRyCTVTTLS
0 1 T525‑p WDPAVRMtPGQALRH
  DYRK2 iso2  
- gap
- gap
T33 NKRTVLTTQPNGLTT
S69 GSSTSLKSMEGMGKV
Y307 CYEHQRVYTYIQSRF
T308 YEHQRVYTYIQSRFY
Y309 EHQRVYTYIQSRFYR
Y315 TYIQSRFYRAPEVIL
S369 IELLGMPSQKLLDAS
S376 SQKLLDASKRAKNFV
Y391 SSKGYPRYCTVTTLS
T452 WDPAVRMTPGQALRH
  mouse

 
S30‑p AVRQLQAsPGIGAGA
S48‑p GVGTGPPsPIALPPL
T104 NKRTVLTTQPNGLTT
S140 GSSTSLKSMEGMGKV
Y378 CYEHQRVYtyIQSRF
T379‑p YEHQRVYtyIQSRFY
Y380‑p EHQRVYtyIQSRFYR
Y386 tyIQSRFYRAPEVIL
S440 IELLGMPSQKLLDAS
S447 SQKLLDASKRAKNFV
Y462 SSKGYPRYCTVTTLS
T523 WDPAVRMTPGQALRH
  rat

 
- gap
- gap
T32 NKRTVLTTQPNGLTT
S68 GSSTSLKSMEGMGKV
Y306 CYEHQRVYTyIQSRF
T307 YEHQRVYTyIQSRFy
Y308‑p EHQRVYTyIQSRFyR
Y314‑p TyIQSRFyRAPEVIL
S368 IELLGMPSQKLLDAS
S375 SQKLLDASKRAKNFV
Y390 SSKGYPRYCTVTTLS
T451 WDPAVRMTPGQALRH
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