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Protein Page:
DYRK2 (human)

Overview
DYRK2 a dual-specificity protein kinase of the DYRK family. Localizes in the cytoplasm. Phosphorylates the translation initiation factor eIF2B at Ser539, priming it for phosphorylation by glycogen synthase kinase-3. Note: This description may include information from UniProtKB.
Protein type: CMGC group; DYRK family; Dyrk2 subfamily; EC 2.7.12.1; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor)
Chromosomal Location of Human Ortholog: 12q15
Cellular Component: cytoplasm; nucleoplasm; nucleus; ubiquitin ligase complex
Molecular Function: ATP binding; magnesium ion binding; manganese ion binding; protein binding; protein serine/threonine kinase activity; protein-tyrosine kinase activity; ubiquitin binding
Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; negative regulation of NFAT protein import into nucleus; positive regulation of glycogen biosynthetic process; protein amino acid phosphorylation; response to DNA damage stimulus; smoothened signaling pathway
Reference #:  Q92630 (UniProtKB)
Alt. Names/Synonyms: Dual specificity tyrosine-phosphorylation-regulated kinase 2; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2; DYRK2; FLJ21217; FLJ21365
Gene Symbols: DYRK2
Molecular weight: 66,652 Da
Basal Isoelectric point: 9.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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DYRK2

Protein Structure Not Found.
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