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Protein Page:
DYRK1B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DYRK1B a dual-specificity protein kinase of the DYRK family. Localizes in the nucleus, where it enhances the transcriptional activity of TCF1/HNF1A. A co-activator of FKHR (FOXO1a)-dependent glucose-6-phosphatase gene expression. Induced by members of the Rho-family in myoblasts. Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines. Contains a bipartite nuclear targeting signal sequence. Three splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, CMGC; Kinase, protein; EC 2.7.12.1; Protein kinase, dual-specificity (non-receptor); CMGC group; DYRK family; Dyrk1 subfamily
Chromosomal Location of Human Ortholog: 19q13.2
Molecular Function: protein binding; protein kinase activity; transcription coactivator activity
Biological Process: positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation
Disease: Abdominal Obesity-metabolic Syndrome 3
Reference #:  Q9Y463 (UniProtKB)
Alt. Names/Synonyms: Dual specificity tyrosine-phosphorylation-regulated kinase 1B; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B; DYR1B; DYRK1B; Minibrain-related kinase; MIRK; Mirk protein kinase
Gene Symbols: DYRK1B
Molecular weight: 69,198 Da
Basal Isoelectric point: 9.25  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DYRK1B

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: S421‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 1 S49‑p SAPLRKLsVDLIKTY
0 3 K57‑ac VDLIKTYkHINEVyY
0 25 Y63‑p YkHINEVyYAKKKRR
3 184 Y271‑p CQLGQRIyQyIQsRF
6 3576 Y273‑p LGQRIyQyIQsRFYR
0 375 S276‑p RIyQyIQsRFYRSPE
1 2 S421‑p YEPAARIsPLGALQH
0 1 Y485‑p SDNRTYRysNRYCGG
0 1 S486‑p DNRTYRysNRYCGGP
  DYRK1B iso2  
S49 SAPLRKLSVDLIKTY
K57 VDLIKTYKHINEVYY
Y63 YKHINEVYYAKKKRR
Y271 CQLGQRIYQYIQSRF
Y273 LGQRIYQYIQSRFYR
S276 RIYQYIQSRFYRSPE
S381 YEPAARISPLGALQH
Y445 SDNRTYRYSNRYCGG
S446 DNRTYRYSNRYCGGP
  mouse

 
S49 SAPLRKLSVDLIKTY
K57 VDLIKTYKHINEVyY
Y63‑p YKHINEVyYAKKKRR
Y271‑p CQLGQRIyQyIQsRF
Y273‑p LGQRIyQyIQsRFYR
S276‑p RIyQyIQsRFYRSPE
S421‑p YEPAARIsPLGALQH
Y485 NDNRAYRYSNRYCGG
S486 DNRAYRYSNRYCGGP
  rat

 
S49 SAPLRKLSVDLIKTY
K57‑ac VDLIKTYkHINEVYY
Y63 YkHINEVYYAKKKRR
Y271 CQLGQRIYQyIQsRF
Y273‑p LGQRIYQyIQsRFYR
S276‑p RIYQyIQsRFYRSPE
S381 YEPAARISPLGALQH
Y445 SDNRAYRYSNRYCGG
S446 DNRAYRYSNRYCGGP
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