Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. Monomer. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interacts with PDIA3/ERp57. Interacts with NR3C1 and TRIM21. Interacts with GABARAP. Belongs to the calreticulin family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Nuclear receptor co-regulator; Calcium-binding; Motility/polarity/chemotaxis; Secreted
Molecular Function: androgen receptor binding; calcium ion binding; carbohydrate binding; chaperone binding; complement component C1q binding; DNA binding; glycoprotein binding; hormone binding; integrin binding; iron ion binding; mRNA binding; peptide binding; protein binding; ubiquitin protein ligase binding; unfolded protein binding; zinc ion binding
Biological Process: antigen processing and presentation of peptide antigen via MHC class I; cardiac muscle cell differentiation; cell cycle arrest; cellular calcium ion homeostasis; cortical actin cytoskeleton organization and biogenesis; glucocorticoid receptor signaling pathway; negative regulation of neuron differentiation; negative regulation of retinoic acid receptor signaling pathway; negative regulation of steroid hormone receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of translation; peptide antigen assembly with MHC class I protein complex; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of phagocytosis; protein export from nucleus; protein folding; protein maturation via protein folding; protein stabilization; receptor-mediated endocytosis; regulation of apoptosis; regulation of meiosis; regulation of transcription, DNA-dependent; response to drug; response to estradiol stimulus; response to testosterone stimulus; sequestering of calcium ion; spermatogenesis
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.