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Protein Page:
EHMT2 iso4 (human)

Overview
EHMT2 iso4 Histone methyltransferase. Preferentially methylates 'Lys-9' of histone H3 and 'Lys-27' of histone H3 (in vitro). H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. Also methylates histone H1. Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with GFI1B, WIZ and EHMT1. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine
Chromosomal Location of Human Ortholog: 6p21.31
Cellular Component: nuclear chromatin; nucleoplasm; nucleus
Molecular Function: histone lysine N-methyltransferase activity (H3-K27 specific); histone lysine N-methyltransferase activity (H3-K9 specific); histone-lysine N-methyltransferase activity; p53 binding; protein binding; protein-lysine N-methyltransferase activity
Biological Process: cellular response to starvation; DNA methylation; histone methylation; negative regulation of transcription from RNA polymerase II promoter; peptidyl-lysine di-methylation; regulation of DNA replication
Reference #:  A2ABF8 (UniProtKB)
Alt. Names/Synonyms: ankyrin repeat-containing protein; BAT8; C6orf30; DKFZp686H08213; EHMT2; Euchromatic histone-lysine N-methyltransferase 2; FLJ35547; G9A; G9A histone methyltransferase; H3-K9-HMTase 3; Histone H3-K9 methyltransferase 3; Histone-lysine N-methyltransferase, H3 lysine-9 specific 3; HLA-B associated transcript 8; HLA-B-associated transcript 8; KMT1C; Lysine N-methyltransferase 1C; NG36; Protein G9a
Gene Symbols: EHMT2
Molecular weight: 135,418 Da
Basal Isoelectric point: 5.81  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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EHMT2 iso4

Protein Structure Not Found.
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