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Protein Page:
STAM1 (human)

STAM1 Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. Belongs to the STAM family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 10p14-p13
Cellular Component: cytosol
Molecular Function: protein binding; SH3/SH2 adaptor activity
Biological Process: autophagy; endosome transport; negative regulation of epidermal growth factor receptor signaling pathway; signal transduction
Reference #:  Q92783 (UniProtKB)
Alt. Names/Synonyms: DKFZp686J2352; HSE1 homolog; Signal transducing adapter molecule 1; signal transducing adaptor molecule (SH3 domain and ITAM motif) 1; STAM; STAM-1; STAM1
Gene Symbols: STAM
Molecular weight: 59,180 Da
Basal Isoelectric point: 4.7  Predict pI for various phosphorylation states
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