an ubiquitous protein kinase of the CK1 family. Enriched at the centrosomes in interphase and at the spindle during mitosis. May play a role in cell cycle progression. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, CK1; EC 188.8.131.52; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 184.108.40.206; CK1 group; CK1 family
Molecular Function: ATP binding; glycoprotein binding; peptide binding; phosphoprotein binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; tau-protein kinase activity
Biological Process: cellular protein metabolic process; circadian regulation of gene expression; COPII coating of Golgi vesicle; DNA repair; ER to Golgi vesicle-mediated transport; G2/M transition of mitotic cell cycle; Golgi organization and biogenesis; microtubule nucleation; mitotic cell cycle; organelle organization and biogenesis; peptidyl-serine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein amino acid phosphorylation; post-translational protein modification; protein amino acid N-linked glycosylation via asparagine; protein amino acid phosphorylation; protein localization in Golgi apparatus; regulation of circadian rhythm; sensory cilium biogenesis; signal transduction; spindle assembly; Wnt receptor signaling pathway
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.