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Protein Page:
CDK8 (human)

CDK8 a protein kinase of the CDK family. Along with cyclin C forms part of the RNA polymerase II holoenzyme complex. Phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. Regulates transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK8 subfamily; CMGC group; Cell cycle regulation; EC; EC; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 13q12
Cellular Component: nucleoplasm; nucleus; Srb-mediator complex
Molecular Function: protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process: positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter
Reference #:  P49336 (UniProtKB)
Alt. Names/Synonyms: CDK8; CDK8 protein kinase; Cell division protein kinase 8; Cyclin-dependent kinase 8; K35; Mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8; MGC126074; MGC126075; Protein kinase K35
Gene Symbols: CDK8
Molecular weight: 53,284 Da
Basal Isoelectric point: 8.72  Predict pI for various phosphorylation states
CST Pathways:  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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