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Protein Page:
Akt3 (human)

Overview
Akt3 an AGC kinase that plays a critical role in controlling the balance between survival and apoptosis. Stimulated by platelet-derived growth factor, insulin, and insulin-like growth factor 1. Alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: AGC group; AKT family; EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 1q44
Cellular Component: cytoplasm; Golgi apparatus; intracellular; nucleoplasm; plasma membrane
Molecular Function: ATP binding; protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process: mitochondrial genome maintenance; peptidyl-serine phosphorylation; protein amino acid phosphorylation; signal transduction
Disease: Megalencephaly-polymicrogyria-polydactyly-hydrocephalus Syndrome 2
Reference #:  Q9Y243 (UniProtKB)
Alt. Names/Synonyms: AKT3; DKFZp434N0250; PKB gamma; PKB-GAMMA; PKBG; PRKBG; Protein kinase Akt-3; Protein kinase B gamma; RAC-gamma; RAC-gamma serine/threonine protein kinase; RAC-gamma serine/threonine-protein kinase; RAC-PK-gamma; serine threonine protein kinase, Akt-3; STK-2; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
Gene Symbols: AKT3
Molecular weight: 55,775 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Alzheimer's Disease  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  G1/S Checkpoint  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Akt3

Protein Structure Not Found.
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