an AGC kinase. Plays critical roles in glucose metabolism and the development or maintenance of proper adipose tissue and islet mass for which other Akt/PKB isoforms are unable to fully compensate. Amplified and overexpressed in human ovarian carcinoma cell lines and amplified in some primary ovarian and pancreatic tumors. Antisense blocks invasiveness in xenografts. Expressed in several insulin-responsive tissues, and one case of Type II diabetes has been associated with a likely LOF point mutation. Mouse mutants have defects in insulin response. Note: This description may include information from UniProtKB.
Protein type: EC 18.104.22.168; Kinase, protein; Protein kinase, AGC; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); AGC group; AKT family
Molecular Function: ATP binding; protein binding; protein kinase C binding; protein serine/threonine kinase activity
Biological Process: carbohydrate transport; cellular response to insulin stimulus; fat cell differentiation; glucose metabolic process; glycogen biosynthetic process; insulin receptor signaling pathway; intracellular protein transport across a membrane; myelin maintenance in the peripheral nervous system; negative regulation of caspase activity; negative regulation of RNA splicing; peptidyl-serine phosphorylation; positive regulation of cell migration; positive regulation of fatty acid beta-oxidation; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; positive regulation of nitric oxide biosynthetic process; positive regulation of peptidyl-serine phosphorylation; positive regulation of positive chemotaxis; positive regulation of protein amino acid phosphorylation; positive regulation of signal transduction; positive regulation of transcription from RNA polymerase II promoter; positive regulation of vesicle fusion; protein kinase B signaling cascade; protein modification process; regulation of cell migration; regulation of translation; response to muscle activity; response to nutrient levels; response to osmotic stress; signal transduction
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.