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Protein Page:
NGFR (human)

Overview
NGFR Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor. Interacts with LINGO1. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 17q21-q22
Cellular Component: cell surface; clathrin-coated endocytic vesicle; cytosol; endosome; external side of plasma membrane; extracellular region; Golgi apparatus; integral to plasma membrane; lipid raft; neuron projection; nuclear envelope; nucleoplasm; nucleus; perikaryon; plasma membrane; rough endoplasmic reticulum
Molecular Function: beta-amyloid binding; nerve growth factor binding; neurotrophin TRKA receptor binding; protein binding; Rab GTPase binding; receptor activity; signal transducer activity; transmembrane receptor activity; tumor necrosis factor receptor activity; ubiquitin protein ligase binding
Biological Process: axon guidance; caspase activation; circadian regulation of gene expression; glucose homeostasis; immune response; inflammatory response; intracellular protein transport; membrane protein intracellular domain proteolysis; negative regulation of apoptosis; negative regulation of axonogenesis; negative regulation of caspase activity; negative regulation of mitochondrial depolarization; negative regulation of neuron apoptosis; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of axonogenesis; positive regulation of MAPKKK cascade; positive regulation of myelination; positive regulation of protein kinase B signaling cascade; positive regulation of Rho protein signal transduction; positive regulation of synaptic transmission, cholinergic; positive regulation of synaptic transmission, glutamatergic; regulation of apoptosis; regulation of caspase activity; regulation of cell proliferation; response to lipopolysaccharide; response to wounding; sensory perception of pain; tumor necrosis factor-mediated signaling pathway
Reference #:  P08138 (UniProtKB)
Gene Symbols: NGFR
Molecular weight: 45,183 Da
Basal Isoelectric point: 4.59  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NGFR

Protein Structure Not Found.
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Sites Implicated In
cell growth, altered: S303‑p
cytoskeletal reorganization: S303‑p
intracellular localization: S303‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 1 S277‑p IAFKRWNsCKQNKQG
1 0 S287‑p QNKQGANsRPVNQtP
0 3 T293‑p NsRPVNQtPPPEGEK
2 0 S303‑p PEGEKLHsDsGIsVD
1 0 S305‑p GEKLHsDsGIsVDsQ
1 0 S308‑p LHsDsGIsVDsQsLH
1 1 S311‑p DsGIsVDsQsLHDQQ
1 1 S313‑p GIsVDsQsLHDQQPH
1 1 S325‑p QPHTQTAsGQALKGD
1 4 Y336‑p LKGDGGLySSLPPAK
0 1 A342 LySSLPPAKREEVEK
1 0 S425‑p CSESTATsPV_____
  mouse

 
S270 IAFKRWNSCKQNKQG
S280 QNKQGANSRPVNQtP
T286‑p NSRPVNQtPPPEGEK
S296 PEGEKLHSDSGISVD
S298 GEKLHSDSGISVDSQ
S301 LHSDSGISVDSQSLH
S304 DSGISVDSQSLHDQQ
S306 GISVDSQSLHDQQTH
S318 QTHTQTASAQALKGD
Y329‑p LKGDGNLySSLPLtK
T335‑p LySSLPLtKREEVEK
S415 CSESTATSPV_____
  rat

 
S278‑p IAFKRWNsCKQNKQG
S288 QNKQGANSRPVNQTP
T294 NSRPVNQTPPPEGEK
S304 PEGEKLHSDSGISVD
S306 GEKLHSDSGISVDSQ
S309 LHSDSGISVDSQSLH
S312 DSGISVDSQSLHDQQ
S314 GISVDSQSLHDQQTH
S326 QTHTQTASGQALKGD
Y337‑p LKGDGNLySSLPLTK
T343 LySSLPLTKREEVEK
S423 CSESTATSPV_____
  chicken

 
S266‑p IAFKRWNsCKQNKQG
N276 QNKQGANNRPVNQTP
T282 NNRPVNQTPSPEGEK
S292 PEGEKLHSDSGISVD
S294 GEKLHSDSGISVDSQ
S297 LHSDSGISVDSQSLH
S300 DSGISVDSQSLHDQQ
S302 GISVDSQSLHDQQPP
T313 QQPPNQSTQGPAPKG
Y325 PKGDGSLYASLPPSK
S331 LYASLPPSKQEEVEK
S414 YSESTATSPV_____
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