a zinc finger protein that plays an important role in the assembly of the RNA polymerase III initiation factor TFIIIB. Regulates mRNA levels by targeting transcripts containing AREs (AU-rich elements) into the decay pathway. Phosphorylation by Akt apparently generates 14-3-3 binding sites and inhibits BRF1 from promoting mRNA activity.Contains 2 C3H1-type zinc fingers. Note: This description may include information from UniProtKB.
Molecular Function: mRNA 3'-UTR binding; mRNA binding; protein binding
Biological Process: cellular response to insulin stimulus; MAPKKK cascade; mesendoderm development; mRNA catabolic process, deadenylation-independent decay; mRNA transport; negative regulation of erythrocyte differentiation; phosphoinositide 3-kinase cascade; positive regulation of fat cell differentiation; positive regulation of monocyte differentiation; protein kinase B signaling cascade; regulation of gene expression; regulation of keratinocyte differentiation; regulation of mRNA 3'-end processing; regulation of mRNA stability; regulation of myoblast differentiation; response to wounding; T cell differentiation in the thymus