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Protein Page:
TGFBR2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TGFBR2 a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Binds to DAXX. Defects can cause esophageal cancer. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TKL; EC 2.7.11.30; Membrane protein, integral; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (receptor); TKL group; STKR family; Type2 subfamily
Chromosomal Location of Human Ortholog: 3p22
Cellular Component: caveola; cytosol; external side of plasma membrane; integral to membrane; lipid raft; plasma membrane; receptor complex
Molecular Function: ATP binding; glycosaminoglycan binding; metal ion binding; mitogen-activated protein kinase kinase kinase binding; protein binding; receptor signaling protein serine/threonine kinase activity; SMAD binding; transforming growth factor beta binding; transforming growth factor beta receptor activity; transforming growth factor beta receptor activity, type II; transmembrane receptor protein serine/threonine kinase activity
Biological Process: activation of protein kinase activity; aging; apoptosis; blood vessel development; brain development; common-partner SMAD protein phosphorylation; embryo implantation; embryonic cranial skeleton morphogenesis; embryonic hemopoiesis; gastrulation; gut development; heart development; in utero embryonic development; lens development in camera-type eye; myeloid dendritic cell differentiation; negative regulation of cardiac muscle cell proliferation; negative regulation of transforming growth factor beta receptor signaling pathway; Notch signaling pathway; organ regeneration; palate development; patterning of blood vessels; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of angiogenesis; positive regulation of B cell tolerance induction; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of NK T cell differentiation; positive regulation of skeletal muscle regeneration; positive regulation of smooth muscle cell proliferation; positive regulation of T cell tolerance induction; positive regulation of tolerance induction to self antigen; protein amino acid phosphorylation; receptor-mediated endocytosis; regulation of cell proliferation; regulation of gene expression; response to drug; response to estrogen stimulus; response to glucose stimulus; response to mechanical stimulus; response to nutrient; smoothened signaling pathway; transforming growth factor beta receptor signaling pathway; vasculogenesis; wound healing
Disease: Colorectal Cancer, Hereditary Nonpolyposis, Type 6; Esophageal Cancer; Loeys-dietz Syndrome 2
Reference #:  P37173 (UniProtKB)
Alt. Names/Synonyms: AAT3; FAA3; LDS1B; LDS2B; MFS2; RIIC; TAAD2; TbetaR-II; TGF-beta receptor type II; TGF-beta receptor type IIB; TGF-beta receptor type-2; TGF-beta type II receptor; TGFbeta-RII; TGFBR2; TGFR-2; TGFR2; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II (70/80kDa); Transforming growth factor-beta receptor type II
Gene Symbols: TGFBR2
Molecular weight: 64,568 Da
Basal Isoelectric point: 5.6  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TGFBR2

Protein Structure Not Found.
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Sites Implicated In
cell growth, altered: S213‑p, Y284‑p
cytoskeletal reorganization: Y284‑p
transcription, altered: Y259‑p, Y336‑p, Y424‑p
enzymatic activity, induced: Y259‑p, Y336‑p, S409‑p, Y424‑p
enzymatic activity, inhibited: S416‑p
molecular association, regulation: Y284‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S31 IPPHVQKSVNNDMIV
0 1 T39‑ga VNNDMIVtDNNGAVK
0 3 K205‑ub SSTWETGkTRkLMEF
0 1 K208‑ub WETGkTRkLMEFsEH
1 0 S213‑p TRkLMEFsEHCAIIL
1 0 S225 IILEDDRSDISSTCA
1 0 S228 EDDRSDISSTCANNI
1 0 S229 DDRSDISSTCANNIN
2 0 Y259‑p KGRFAEVykAKLKQN
1 0 K260‑ne GRFAEVykAKLKQNT
3 0 Y284‑p KIFPYEEyASWKTEK
3 0 Y336‑p AKGNLQEyLTRHVIS
0 1 S352‑p EDLRKLGsSLARGIA
1 4 S409‑p LRLDPTLsVDDLANs
1 0 S416‑p sVDDLANsGQVGTAR
2 6 Y424‑p GQVGTARyMAPEVLE
1 0 Y470‑p AVGEVKDyEPPFGSK
0 1 S486 REHPCVESMkDNVLR
1 0 K488‑ne HPCVESMkDNVLRDR
0 11 S548‑p LEHLDRLsGRsCsEE
1 5 S551‑p LDRLsGRsCsEEkIP
1 10 S553‑p RLsGRsCsEEkIPED
1 0 K556‑ne GRsCsEEkIPEDGsL
0 2 S562‑p EkIPEDGsLNTtk__
0 1 T566‑p EDGsLNTtk______
1 0 K567‑ne DGsLNTtk_______
  TGFBR2 iso2  
S31‑p IPPHVQKsDVEMEAQ
T64 INNDMIVTDNNGAVK
K230 SSTWETGKTRKLMEF
K233 WETGKTRKLMEFSEH
S238 TRKLMEFSEHCAIIL
S250 IILEDDRSDISSTCA
S253 EDDRSDISSTCANNI
S254 DDRSDISSTCANNIN
Y284 KGRFAEVYKAKLKQN
K285 GRFAEVYKAKLKQNT
Y309 KIFPYEEYASWKTEK
Y361 AKGNLQEYLTRHVIS
S377 EDLRKLGSSLARGIA
S434 LRLDPTLSVDDLANS
S441 SVDDLANSGQVGTAR
Y449 GQVGTARYMAPEVLE
Y495 AVGEVKDYEPPFGSK
S511 REHPCVESMKDNVLR
K513 HPCVESMKDNVLRDR
S573 LEHLDRLSGRSCSEE
S576 LDRLSGRSCSEEKIP
S578 RLSGRSCSEEKIPED
K581 GRSCSEEKIPEDGSL
S587 EKIPEDGSLNTTK__
T591 EDGSLNTTK______
K592 DGSLNTTK_______
  mouse

 
S31 IPPHVPKSDVEMEAQ
S64 FNSDVMASDNGGAVK
K230‑ub SPSWESSkPRKLMDF
K233 WESSkPRKLMDFSDN
S238 PRKLMDFSDNCAIIL
S250‑p IILEDDRsDIssTCA
S253‑p EDDRsDIssTCANNI
S254‑p DDRsDIssTCANNIN
Y284 KGRFAEVYKAKLKQN
K285 GRFAEVYKAKLKQNT
Y309‑p KIFPYEEySSWKTEK
Y361 AKGNLQEYLTRHVIS
S377 EDLRKLGSSLARGIA
S434‑p LRLDPTLsVDDLANS
S441 sVDDLANSGQVGTAR
Y449 GQVGTARYMAPEVLE
Y495 AVGEVKDYEPPFGSK
S511‑p REHPCVEsMKDSVLR
K513 HPCVEsMKDSVLRDR
S573 LEHPERLSGRsCsQE
S576‑p PERLSGRsCsQEKIP
S578‑p RLSGRsCsQEKIPED
K581 GRsCsQEKIPEDGSL
S587 EKIPEDGSLNTTK__
T591 EDGSLNTTK______
K592 DGSLNTTK_______
  rat

 
S31 IPPHVPKSVNSDLMA
G39 VNSDLMAGDNSGAVK
K205 SPSWESSKPRKLMDF
K208 WESSKPRKLMDFSDN
S213 PRKLMDFSDNCAIIL
S225 IILEDDRSDISSTCA
S228 EDDRSDISSTCANNI
S229 DDRSDISSTCANNIN
Y259 KGRFAEVYKAKLKQN
K260 GRFAEVYKAKLKQNT
Y284 KIFPYEEYSSWKTEK
Y336 AKGNLQEYLTRHVIS
S352 EDLRKLGSSLARGIA
S409 LRLDPTLSVDDLANS
S416 SVDDLANSGQVGTAR
Y424 GQVGTARYMAPEVLE
Y470 AVGEVKDYEPPFGSK
S486 REHPCVESMKDNVLR
K488 HPCVESMKDNVLRDR
S548‑p LEHPDRLsGRSCSQE
S551 PDRLsGRSCSQEKIP
S553 RLsGRSCSQEKIPED
K556 GRSCSQEKIPEDGSL
S562 EKIPEDGSLNTTK__
T566 EDGSLNTTK______
K567 DGSLNTTK_______
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