a cytoplasmic tyrosine kinase of the SYK family containing two SH2 domains. Plays a central role in the B cell receptor (BCR) response. An upstream activator of the PI3K, PLCgamma2, and Rac/cdc42 pathways in the BCR response. Required for the sequential events of Fc gamma IIa receptor-mediated phagocytosis. Expression highest in murine spleen, heart, mammary gland and thymus. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; EC 126.96.36.199; Kinase, protein; Protein kinase, tyrosine (non-receptor); TK group; Syk family
Cellular Component: B cell receptor complex; cytoplasm; cytosol; extrinsic to internal side of plasma membrane; nucleus; plasma membrane; protein complex; T cell receptor complex
Molecular Function: ATP binding; integrin binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein-tyrosine kinase activity; receptor signaling protein tyrosine kinase activity
Biological Process: activation of JNK activity; adaptive immune response; angiogenesis; B cell receptor signaling pathway; beta selection; blood vessel morphogenesis; cell proliferation; defense response to bacterium; inflammatory response; innate immune response; integrin-mediated signaling pathway; leukocyte activation during immune response; leukocyte adhesion; leukotriene biosynthetic process; lymph vessel development; macrophage activation during immune response; neutrophil activation during immune response; neutrophil chemotaxis; organ morphogenesis; peptidyl-serine phosphorylation; platelet activation; positive regulation of alpha-beta T cell differentiation; positive regulation of alpha-beta T cell proliferation; positive regulation of B cell differentiation; positive regulation of bone resorption; positive regulation of calcium-mediated signaling; positive regulation of cell adhesion mediated by integrin; positive regulation of cytokine secretion; positive regulation of gamma-delta T cell differentiation; positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; positive regulation of interferon type I production; positive regulation of interleukin-3 biosynthetic process; positive regulation of mast cell degranulation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of receptor internalization; protein amino acid phosphorylation; receptor internalization; regulation of neutrophil degranulation; regulation of phagocytosis; regulation of superoxide release; regulation of transcription factor activity; serotonin secretion by platelet; stimulatory C-type lectin receptor signaling pathway; transcription factor import into nucleus; transmembrane receptor protein tyrosine kinase signaling pathway; viral reproduction
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.