proto-oncogenic cytoplasmic tyrosine kinase of the SRC family. Highly expressed in certain fully differentiated cells such as neurons, platelets and macrophages. Phosphorylation of an activation loop tyrosine activates the enzyme; phosphorylation of a tyrosine in the C-terminus by Csk inhibits the enzyme. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, tyrosine (non-receptor); EC 220.127.116.11; Oncoprotein; Protein kinase, TK; Kinase, protein; TK group; Src family
Cellular Component: actin filament; caveola; cytoplasm; cytosol; extrinsic to internal side of plasma membrane; late endosome; lysosome; mitochondrial inner membrane; mitochondrion; neuron projection; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density
Molecular Function: ATP binding; enzyme binding; ephrin receptor binding; estrogen receptor binding; heme binding; hormone receptor binding; insulin receptor binding; integrin binding; kinase activity; kinase binding; non-membrane spanning protein tyrosine kinase activity; phosphoprotein binding; protein binding; protein C-terminus binding; protein kinase activity; protein kinase C binding; protein-tyrosine kinase activity; receptor binding; SH2 domain binding; SH3/SH2 adaptor activity
Biological Process: activation of protein kinase B; bone resorption; cell cycle; cell proliferation; cell-cell adhesion; cellular response to insulin stimulus; central nervous system development; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; estrogen receptor signaling pathway; forebrain development; innate immune response; integrin-mediated signaling pathway; leukocyte migration; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of focal adhesion formation; negative regulation of mitochondrial depolarization; negative regulation of protein homooligomerization; negative regulation of telomerase activity; negative regulation of telomere maintenance via telomerase; negative regulation of transcription, DNA-dependent; nerve growth factor receptor signaling pathway; oogenesis; peptidyl-serine phosphorylation; peptidyl-tyrosine phosphorylation; platelet activation; platelet-derived growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of cyclin-dependent protein kinase activity; positive regulation of cytokine secretion; positive regulation of insulin receptor signaling pathway; positive regulation of integrin activation; positive regulation of MAP kinase activity; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of protein amino acid autophosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of smooth muscle cell migration; positive regulation of transcription, DNA-dependent; progesterone receptor signaling pathway; protein amino acid autophosphorylation; protein destabilization; regulation of bone resorption; regulation of cell cycle; regulation of cell proliferation; regulation of cell-cell adhesion; regulation of estrogen receptor signaling pathway; regulation of protein binding; regulation of vascular permeability; response to acidity; response to drug; response to electrical stimulus; response to hydrogen peroxide; response to mechanical stimulus; response to mineralocorticoid stimulus; response to nutrient levels; response to virus; signal complex assembly; signal transduction; stimulatory C-type lectin receptor signaling pathway; stress fiber formation; T cell costimulation; transcytosis; transforming growth factor beta receptor signaling pathway; uterus development; vascular endothelial growth factor receptor signaling pathway; viral reproduction
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.