dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38 but not ERK1 or -2. Mediates cellular responses to various cellular stresses and inflammatory cytokines. Phosphorylation by Akt inhibits MKK4 and suppresses stress-activated signal transduction. Note: This description may include information from UniProtKB.
Protein type: EC 22.214.171.124; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Molecular Function: protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process: activation of protein kinase activity; JNK cascade; regulation of apoptosis; regulation of mitotic cell cycle; signal transduction; stress-activated protein kinase signaling pathway