an AGC kinase of the RSK family. Phosphorylated and activated by Erk1 and -2 in response to many growth factors, polypeptide hormones and neurotransmitters. Several phosphorylation sites are important for its activation. Possesses two kinase domains connected by a regulator linker region. Phosphorylates a wide range of substrates including ribosomal protein S6. Prominently expressed in brain structures essential for cognitive function and learning. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC 220.127.116.11; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); RSK family; RSK subfamily
Molecular Function: caspase inhibitor activity; kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process: central nervous system development; negative regulation of apoptosis; negative regulation of caspase activity; peptidyl-serine phosphorylation; positive regulation of cell differentiation; positive regulation of cell growth; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription in response to stress; regulation of translation in response to stress; response to lipopolysaccharide; signal transduction; skeletal development; toll-like receptor signaling pathway