Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
RSK2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RSK2 an AGC kinase of the RSK family. Phosphorylated and activated by Erk1 and -2 in response to many growth factors, polypeptide hormones and neurotransmitters. Several phosphorylation sites are important for its activation. Possesses two kinase domains connected by a regulator linker region. Phosphorylates a wide range of substrates including ribosomal protein S6. Prominently expressed in brain structures essential for cognitive function and learning. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); AGC group; RSK family; RSK subfamily
Chromosomal Location of Human Ortholog: Xp22.2-p22.1
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: caspase inhibitor activity; kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process: central nervous system development; negative regulation of apoptosis; negative regulation of caspase activity; positive regulation of cell differentiation; positive regulation of cell growth; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription in response to stress; regulation of translation in response to stress; response to lipopolysaccharide; signal transduction; skeletal development; toll-like receptor signaling pathway
Disease: Coffin-lowry Syndrome; Mental Retardation, X-linked 19
Reference #:  P51812 (UniProtKB)
Alt. Names/Synonyms: 90 kDa ribosomal protein S6 kinase 3; CLS; HU-3; Insulin-stimulated protein kinase 1; ISPK-1; ISPK1; KS6A3; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; MAPKAPK1B; mental retardation, X-linked 19; MRX19; p90-RSK 3; p90-RSK2; p90RSK3; pp90RSK2; Ribosomal protein S6 kinase alpha-3; ribosomal protein S6 kinase, 90kDa, polypeptide 3; Ribosomal S6 kinase 2; RPS6KA3; RSK; RSK-2; RSK2; S6K-alpha-3; S6K-alpha3
Gene Symbols: RPS6KA3
Molecular weight: 83,736 Da
Basal Isoelectric point: 6.41  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  G2/M DNA Damage Checkpoint  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RSK2

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

Substrate Sequence Logo
Sequence Logo

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
apoptosis, altered: Y529‑p
cell growth, induced: Y529‑p
cell motility, induced: Y529‑p
transcription, induced: S369‑p
enzymatic activity, induced: S227‑p, S369‑p, T577‑p
molecular association, regulation: Y529‑p
protein conformation: S369‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S17‑p WQKMAVEsPsDSAEN
0 2 S19‑p KMAVEsPsDSAENGQ
0 2 K72‑ub PSQFELLkVLGQGsF
0 2 S78‑p LkVLGQGsFGkVFLV
0 3 K81‑ac LGQGsFGkVFLVKKI
0 1 K100‑ac ARQLYAMkVLkKATL
0 1 K103‑ac LYAMkVLkKATLKVR
0 2 R192 HSLGIIYRDLKPENI
0 1 S215 KLTDFGLSKESIDHE
0 42 Y226‑p IDHEKKAysFCGtVE
11 180 S227‑p DHEKKAysFCGtVEy
0 64 T231‑p KAysFCGtVEyMAPE
0 9 Y234‑p sFCGtVEyMAPEVVN
0 2 K274 PFQGKDRKETMtMIL
0 1 T278‑p KDRKETMtMILKAKL
0 2 K282 ETMtMILKAKLGMPQ
0 1 K284 MtMILKAKLGMPQFL
0 6 K322‑ub PDGVEEIkRHSFFST
0 1 S325 VEEIkRHSFFSTIDW
0 1 S328 IkRHSFFSTIDWNKL
0 1 T348 HPPFKPATGRPEDTF
0 4 Y356‑p GRPEDTFyFDPEFtA
0 3 T362‑p FyFDPEFtAKtPKDs
6 42 T365‑p DPEFtAKtPKDsPGI
10 58 S369‑p tAKtPKDsPGIPPsA
0 19 S375‑p DsPGIPPsANAHQLF
10 74 S386‑p HQLFRGFsFVAItsD
0 1 T391‑p GFsFVAItsDDEsQA
0 3 S392‑p FsFVAItsDDEsQAM
0 2 S396‑p AItsDDEsQAMQTVG
0 25 S415‑p VQQLHRNsIQFTDGY
1 6 Y470‑p EIEILLRyGQHPNII
0 2 T478‑p GQHPNIItLKDVyDD
1 6 Y483‑p IItLKDVyDDGKyVY
2 16 Y488‑p DVyDDGKyVYVVTEL
0 1 Y490 yDDGKyVYVVTELMK
0 1 S517‑p FFSEREAsAVLFTIT
4 5 Y529‑p TITKTVEyLHAQGVV
0 1 S556‑p DESGNPEsIRICDFG
0 3 K566 ICDFGFAKQLRAENG
8 186 T577‑p AENGLLMtPCytANF
1 85 Y580‑p GLLMtPCytANFVAP
0 27 T581‑p LLMtPCytANFVAPE
1 3 Y644‑p KFSLSGGyWNSVSDT
0 20 Y688‑p HWDQLPQyQLNRQDA
0 1 T706‑p VKGAMAAtysALNRN
2 86 Y707‑p KGAMAAtysALNRNQ
0 1 S708‑p GAMAAtysALNRNQs
0 67 S715‑p sALNRNQsPVLEPVG
0 4 S737‑p RGIKKITsTAL____
3556 : Phospho-RSK2 (Ser227) (D53A11) Rabbit mAb
9335 : Phospho-p90RSK (Ser380) (9D9) Rabbit mAb
9341 : Phospho-p90RSK (Ser380) Antibody
11989 : Phospho-p90RSK (Ser380) (D3H11) Rabbit mAb
12032 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb
13397 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (PE Conjugate)
13575 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
13588 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
9324 : Phospho-RSK2 (Tyr529) Antibody
  mouse

 
S17 WQKMAVESPsDSAEN
S19‑p KMAVESPsDSAENGQ
K72 PSQFELLKVLGQGSF
S78 LKVLGQGSFGKVFLV
K81 LGQGSFGKVFLVKKI
K100 ARQLYAMKVLKKATL
K103 LYAMKVLKKATLKVR
R192‑m1 HSLGIIYrDLKPENI
S215‑p KLTDFGLsKESIDHE
Y226‑p IDHEKKAysFCGtVE
S227‑p DHEKKAysFCGtVEy
T231‑p KAysFCGtVEyMAPE
Y234‑p sFCGtVEyMAPEVVN
K274‑ub PFQGKDRkETMTMIL
T278 KDRkETMTMILkAkL
K282‑ub ETMTMILkAkLGMPQ
K284‑ac MTMILkAkLGMPQFL
K322 PDGVEEIKRHsFFsT
S325‑p VEEIKRHsFFsTIDW
S328‑p IKRHsFFsTIDWNKL
T348‑p HPPFKPAtGRPEDTF
Y356 GRPEDTFYFDPEFTA
T362 FYFDPEFTAKtPKDs
T365‑p DPEFTAKtPKDsPGI
S369‑p TAKtPKDsPGIPPsA
S375‑p DsPGIPPsANAHQLF
S386‑p HQLFRGFsFVAITSD
T391 GFsFVAITSDDESQA
S392 FsFVAITSDDESQAM
S396 AITSDDESQAMQTVG
S415‑p VQQLHRNsIQFTDGY
Y470‑p EIEILLRyGQHPNII
T478‑p GQHPNIItLKDVyDD
Y483‑p IItLKDVyDDGKyVy
Y488‑p DVyDDGKyVyVVTEL
Y490‑p yDDGKyVyVVTELMK
S517 FFSEREASAVLFTIT
Y529‑p TITKTVEyLHAQGVV
S556 DESGNPESIRICDFG
K566‑ub ICDFGFAkQLRAENG
T577‑p AENGLLMtPCYtANF
Y580 GLLMtPCYtANFVAP
T581‑p LLMtPCYtANFVAPE
Y644 KFSLSGGYWNSVSDT
Y688 HWDQLPQYQLNRQDA
T706 VKGAMAATYSALNRN
Y707 KGAMAATYSALNRNQ
S708 GAMAATYSALNRNQs
S715‑p SALNRNQsPVLEPVG
S737‑p RGIKKITsTAL____
3556 : Phospho-RSK2 (Ser227) (D53A11) Rabbit mAb
9335 : Phospho-p90RSK (Ser380) (9D9) Rabbit mAb
9341 : Phospho-p90RSK (Ser380) Antibody
11989 : Phospho-p90RSK (Ser380) (D3H11) Rabbit mAb
12032 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb
13397 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (PE Conjugate)
13575 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
13588 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
9324 : Phospho-RSK2 (Tyr529) Antibody
  rat

 
S17 WQKMAVESPSDSAEN
S19 KMAVESPSDSAENGQ
K72 PSQFELLKVLGQGSF
S78 LKVLGQGSFGKVFLV
K81 LGQGSFGKVFLVKKI
K100 ARQLYAMKVLKKATL
K103 LYAMKVLKKATLKVR
R192 HSLGIIYRDLKPENI
S215 KLTDFGLSKESIDHE
Y226 IDHEKKAYsFCGTVE
S227‑p DHEKKAYsFCGTVEY
T231 KAYsFCGTVEYMAPE
Y234 sFCGTVEYMAPEVVN
K274 PFQGKDRKETMTMIL
T278 KDRKETMTMILKAKL
K282 ETMTMILKAKLGMPQ
K284 MTMILKAKLGMPQFL
K322 PDGVEEIKRHSFFST
S325 VEEIKRHSFFSTIDW
S328 IKRHSFFSTIDWNKL
T348 HPPFKPATGRPEDTF
Y356 GRPEDTFYFDPEFTA
T362 FYFDPEFTAKtPKDs
T365‑p DPEFTAKtPKDsPGI
S369‑p TAKtPKDsPGIPPsA
S375‑p DsPGIPPsANAHQLF
S386 HQLFRGFSFVAITSD
T391 GFSFVAITSDDESQA
S392 FSFVAITSDDESQAM
S396 AITSDDESQAMQTVG
S415‑p VQQLHRNsIQFTDGY
Y470 EIEILLRYGQHPNII
T478 GQHPNIITLKDVYDD
Y483 IITLKDVYDDGKYVY
Y488 DVYDDGKYVYVVTEL
Y490 YDDGKYVYVVTELMK
S517 FFSEREASAVLFTIT
Y529 TITKTVEYLHTQGVV
S556 DESGNPESIRICDFG
K566 ICDFGFAKQLRAENG
T577 AENGLLMTPCYTANF
Y580 GLLMTPCYTANFVAP
T581 LLMTPCYTANFVAPE
Y644 KFSLSGGYWNSVSDT
Y688 HWDQLPQYQLNRQDA
T706 VKGAMAATYSALNRN
Y707 KGAMAATYSALNRNQ
S708 GAMAATYSALNRNQs
S715‑p SALNRNQsPVLEPVG
S737 RGIKKITSTAL____
3556 : Phospho-RSK2 (Ser227) (D53A11) Rabbit mAb
9335 : Phospho-p90RSK (Ser380) (9D9) Rabbit mAb
9341 : Phospho-p90RSK (Ser380) Antibody
11989 : Phospho-p90RSK (Ser380) (D3H11) Rabbit mAb
12032 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb
13397 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (PE Conjugate)
13575 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
13588 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.