a nonreceptor tyrosine kinase of the Fak family. Predominantly expressed in the cells derived from hematopoietic lineages and in the central nervous system. Pyk2 is one of the signaling mediators for G-protein-coupled receptors. Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. It plays an important role in cell motility such as spreading and migration. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 188.8.131.52; Fak family; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Cellular Component: cell soma; cytoplasm; cytosol; dendrite; extrinsic to internal side of plasma membrane; focal adhesion; growth cone; lamellipodium; N-methyl-D-aspartate selective glutamate receptor complex; nucleus; perinuclear region of cytoplasm; postsynaptic density
Molecular Function: calmodulin-dependent protein kinase activity; N-methyl-D-aspartate selective glutamate receptor activity; non-membrane spanning protein tyrosine kinase activity; protein binding; protein-tyrosine kinase activity; receptor binding
Biological Process: activation of JAK protein; angiogenesis; apoptosis; bone resorption; cell surface receptor linked signal transduction; cellular defense response; epidermal growth factor receptor signaling pathway; innate immune response; integrin-mediated signaling pathway; ionotropic glutamate receptor signaling pathway; marginal zone B cell differentiation; negative regulation of apoptosis; negative regulation of bone mineralization; negative regulation of cell proliferation; negative regulation of myeloid cell differentiation; negative regulation of neuron apoptosis; negative regulation of potassium ion transport; peptidyl-tyrosine phosphorylation; positive regulation of actin filament polymerization; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; positive regulation of JNK cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of protein kinase activity; positive regulation of synaptic transmission, glutamatergic; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein complex assembly; regulation of cell adhesion; regulation of cell shape; regulation of inositol trisphosphate biosynthetic process; regulation of release of sequestered calcium ion into cytosol; response to stress; signal transduction; sprouting angiogenesis; tumor necrosis factor-mediated signaling pathway; vascular endothelial growth factor receptor signaling pathway