a protein kinase of the PEK family. Upon binding double-stranded RNA, it becomes autophosphorylated and activated. Phosphorylates and inhibits the alpha subunit of eIF2 alpha, which leads to an inhibition of the initiation of protein synthesis. Controls the activation of several transcription factors such as NF-kappaB, p53 and Stats. Mediates apoptosis induced by many different stimuli, such as LPS, TNF-alpha, viral infection and serum starvation. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Other; EC 220.127.116.11; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 18.104.22.168; Translation; Other group; PEK family
Cellular Component: cytoplasm; cytosol; membrane; nucleus; perinuclear region of cytoplasm; ribosome
Molecular Function: ATP binding; double-stranded RNA binding; eukaryotic translation initiation factor 2alpha kinase activity; non-membrane spanning protein tyrosine kinase activity; protein binding; protein kinase activity; protein phosphatase type 2A regulator activity; protein serine/threonine kinase activity
Biological Process: activation of MAPKK activity; activation of NF-kappaB transcription factor; cellular response to amino acid starvation; defense response to virus; evasion by virus of host immune response; innate immune response; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of osteoblast proliferation; negative regulation of translation; negative regulation of viral genome replication; peptidyl-tyrosine phosphorylation; positive regulation of apoptosis; positive regulation of chemokine production; positive regulation of cytokine production; positive regulation of stress-activated MAPK cascade; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of protein phosphatase type 2A activity; response to exogenous dsRNA; response to lipopolysaccharide; response to mechanical stimulus; response to toxin; response to virus; response to vitamin E; transcription, DNA-dependent; translation; unfolded protein response
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.