an AGC protein kinase of the PKC family. A calcium-independent, phospholipid-dependent atypical protein kinase C. Is not activated by phorbolesters or diaglycerol. May play role in the secretory response to nutrients. Involved in cell polarization processes and the formation of epithelial tight junctions. Predominantly expressed in lung and brain, but also expressed at lower levels in many tissues including pancreatic islets. Note: This description may include information from UniProtKB.
Protein type: EC 22.214.171.124; Motility/polarity/chemotaxis; Oncoprotein; Protein kinase, AGC; Tumor suppressor; Protein kinase, Ser/Thr (non-receptor); Cell adhesion; Kinase, protein; Cell development/differentiation; AGC group; PKC family; Iota subfamily
Molecular Function: ATP binding; metal ion binding; phospholipid binding; protein binding; protein domain specific binding; protein kinase activity; protein kinase C activity; protein serine/threonine kinase activity
Biological Process: actin filament organization; activation of NF-kappaB transcription factor; cell migration; cellular response to insulin stimulus; cytoskeleton organization and biogenesis; establishment and/or maintenance of epithelial cell polarity; establishment of apical/basal cell polarity; eye photoreceptor cell development; Golgi vesicle budding; intercellular junction assembly and maintenance; negative regulation of apoptosis; negative regulation of neuron apoptosis; peptidyl-serine phosphorylation; positive regulation of glucose import; protein amino acid phosphorylation; protein targeting to membrane; secretion; vesicle-mediated transport
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.