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Protein Page:
PKCB (human)

PKCB an AGC kinase of the PKC family. A classical PKC downstream of many mitogenic receptors. Activates the NF-kappaB signaling pathway in B cells after antigen-receptor signaling. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: AGC group; Alpha subfamily; EC; Kinase, protein; Motility/polarity/chemotaxis; PKC family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane
Molecular Function: androgen receptor binding; calcium-dependent protein kinase C activity; chromatin binding; histone binding; ligand-dependent nuclear receptor transcription coactivator activity; protein binding; protein kinase C activity; protein kinase C binding; protein serine/threonine kinase activity
Biological Process: activation of NF-kappaB transcription factor; B cell activation; B cell receptor signaling pathway; lipoprotein transport; mitotic nuclear envelope disassembly; negative regulation of insulin receptor signaling pathway; peptidyl-serine phosphorylation; platelet activation; positive regulation of angiogenesis; positive regulation of B cell receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of vascular endothelial growth factor receptor signaling pathway; protein amino acid phosphorylation; regulation of transcription from RNA polymerase II promoter
Reference #:  P05771 (UniProtKB)
Alt. Names/Synonyms: KPCB; MGC41878; PKC beta II; PKC beta2; PKC-B; PKC-beta; PKC-beta II; PKC-beta2; PKCB; PRKCB; PRKCB1; PRKCB2; protein kinase C beta 1; Protein kinase C beta type; protein kinase C, beta; protein kinase C, beta 1 polypeptide
Gene Symbols: PRKCB
Molecular weight: 76,869 Da
Basal Isoelectric point: 6.57  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling  |  Protein Kinase C Signaling
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