Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
PDK1 (human)

PDK1 an AGC kinase of the PKB family that contains a PH domain. Involved in a wide variety of processes including cell proliferation, differentiation and apoptosis. Autophosphorylation in the activation loop is necessary for activity. Phosphorylates and activates kinases including Akt, PKC isozymes, p70 S6K and RSK. Three alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; Kinase, protein; Nuclear receptor co-regulator; PKB family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: cell projection; cytoplasm; cytosol; intracellular; nucleoplasm; plasma membrane
Molecular Function: 3-phosphoinositide-dependent protein kinase activity; kinase activity; phospholipase activator activity; phospholipase binding; protein binding; protein serine/threonine kinase activity
Biological Process: actin cytoskeleton organization and biogenesis; activation of protein kinase B; calcium-mediated signaling; cell migration; cellular response to insulin stimulus; epidermal growth factor receptor signaling pathway; negative regulation of protein kinase activity; negative regulation of transforming growth factor beta receptor signaling pathway; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphoinositide-mediated signaling; platelet activation; positive regulation of release of sequestered calcium ion into cytosol; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of I-kappaB kinase/NF-kappaB cascade; stimulatory C-type lectin receptor signaling pathway; T cell costimulation; T cell receptor signaling pathway
Reference #:  O15530 (UniProtKB)
Alt. Names/Synonyms: 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1; hPDK1; MGC20087; MGC35290; PDK1; PDPK1; PkB kinase like gene 1; PkB-like 1; PRO0461; protein kinase
Gene Symbols: PDPK1
Molecular weight: 63,152 Da
Basal Isoelectric point: 6.95  Predict pI for various phosphorylation states
CST Pathways:  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  T Cell Receptor Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

Substrate Sequence Logo
Sequence Logo

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  InnateDB  |  Ensembl Protein