a protein kinase of the STE20 family that regulates synapse formation and plasticity in the hippocampus. May be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Forms an activated complex with GTP-bound P21, CDC2 and RAC1 proteins. Missense and truncation mutations linked to nonsyndromic mental retardation type 30 (MRX30). Two alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; EC 126.96.36.199; Kinase, protein; STE group; STE20 family; PAKA subfamily
Molecular Function: ATP binding; MAP kinase kinase activity; metal ion binding; protein binding; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity; Rho GTPase binding; SH3 domain binding
Biological Process: activation of MAPK activity; axonogenesis; dendrite development; ephrin receptor signaling pathway; MAPKKK cascade; mitotic cell cycle; positive regulation of neuron apoptosis; regulation of actin filament polymerization; stimulatory C-type lectin receptor signaling pathway; synapse organization and biogenesis; T cell costimulation; T cell receptor signaling pathway
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.