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Protein Page:
PICH (human)

Overview
PICH DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Interacts with PLK1, which phosphorylates it. Both proteins are mutually dependent on each other for correct subcellular localization. Belongs to the SNF2/RAD54 helicase family. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.12; Helicase
Chromosomal Location of Human Ortholog: Xq13.1
Cellular Component: centrosome; cytoplasm; cytosol; membrane; nucleoplasm; plasma membrane
Biological Process: sister chromatid cohesion
Reference #:  Q2NKX8 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent helicase ERCC6-like; DNA excision repair protein ERCC-6-like; ERC6L; ERCC6L; excision repair cross-complementing rodent repair deficiency complementation group 6 - like; excision repair cross-complementing rodent repair deficiency, complementation group 6-like; excision repair protein ERCC6-like; FLJ20105; MGC131695; PICH; PLK1-interacting checkpoint helicase; SNF2/RAD54 family protein; Tumor antigen BJ-HCC-15
Gene Symbols: ERCC6L
Molecular weight: 141,103 Da
Basal Isoelectric point: 5.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PICH

Protein Structure Not Found.


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