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Protein Page:
P38B (human)

Overview
P38B a proline-directed ser/thr MAP kinase, and one of four p38 kinases that play important roles in cellular responses to inflammatory cytokines, DNA damage, oxidative stress, and some GPCRs, leading to direct activation of transcription factors and of other downstream kinases including MSK1, MSK2, eEF2K, MK2, and PRAK. MSK1 and -2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli. MK2 and -3 control gene expression mostly at the post-transcriptional level. eEF2K is important for the elongation of mRNA during translation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17, which then cleaves the ectodomain of TGF-alpha family ligands, a process leading to the activation of EGFR signaling and cell proliferation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, CHOPO, p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. Interacts directly with HDAC3 interacts directly and selectively to repress ATF2 transcriptional activity, and regulate TNF gene expression in LPS-stimulated cells. Inhibited by SB203580 and pyridinyl-imidazole related compounds. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.24; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, CMGC; CMGC group; MAPK family; MAPK/p38 subfamily; p38 subfamily
Chromosomal Location of Human Ortholog: 22q13.33
Cellular Component: cytosol; nucleoplasm
Molecular Function: ATP binding; MAP kinase activity; protein binding; protein serine/threonine kinase activity
Biological Process: activation of MAPK activity; MAPKKK cascade; negative regulation of cardiac muscle cell proliferation; positive regulation of erythrocyte differentiation; positive regulation of muscle cell differentiation; Ras protein signal transduction; regulation of transcription factor activity; response to stress; signal transduction; transcription, DNA-dependent; vascular endothelial growth factor receptor signaling pathway
Reference #:  Q15759 (UniProtKB)
Alt. Names/Synonyms: MAP kinase 11; MAP kinase p38 beta; MAPK 11; MAPK11; Mitogen-activated protein kinase 11; Mitogen-activated protein kinase p38 beta; mitogen-activated protein kinase p38-2; MK11; p38-2; p38b; p38Beta; P38BETA2; PRKM11; SAPK2; SAPK2B; Stress-activated protein kinase 2; stress-activated protein kinase-2; stress-activated protein kinase-2b
Gene Symbols: MAPK11
Molecular weight: 41,357 Da
Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  B Cell Receptor Signaling  |  NF-kB Signaling  |  Phospholipase Signaling  |  Regulation of P38 MAPKs  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Toll-Like Receptor Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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P38B

Protein Structure Not Found.
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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S143‑p RGLKYIHsAGIIHRD
2 57 T180‑p RQADEEMtGyVATRW
1 661 Y182‑p ADEEMtGyVATRWYR
1 0 T241‑p RIMEVVGtPsPEVLA
0 1 S243‑p MEVVGtPsPEVLAKI
1 0 S261‑p HARTYIQsLPPMPQK
1 0 Y323 DEPEAEPYDESVEAK
1 0 S359‑p EPPKPPGsLEIEQ__
  mouse

 
S143 RGLKYIHSAGIIHRD
T180‑p RQADEEMtGyVATRW
Y182‑p ADEEMtGyVATRWYR
T241 RIMEVVGTPSPEVLA
S243 MEVVGTPSPEVLAKI
S261 HARTYIQSLPPMPQK
Y323‑p DEPEAEPyDESVEAK
T359 EPSQLPGTHEIEQ__
  rat

 
S143 RGLKYIHSAGIIHRD
T192 RQADEEMTGyVATRW
Y194‑p ADEEMTGyVATRWYR
T253 RIMEVVGTPSPEVLA
S255 MEVVGTPSPEVLAKI
S273 HARTYIQSLPPMPQK
Y335 DEPEAEPYDESVEAK
T371 ETSQLPGTHEIEQ__
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