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Protein Page:
MSK1 (human)

MSK1 an AGC kinase of the RSK family. Has two kinase domains connected by a regulatory linker region. Enzyme activity requires the presence of both kinase domains. Is phosphorylated and activated by Erk as well as p38 MAPK in response to growth factors and cellular stress. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; Kinase, protein; MSK subfamily; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); RSK family
Chromosomal Location of Human Ortholog: 14q31-q32.1
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: ATP binding; histone serine kinase activity (H3-S10 specific); protein kinase activity; protein serine/threonine kinase activity
Biological Process: activation of CREB transcription factor; activation of NF-kappaB transcription factor; axon guidance; epidermal growth factor receptor signaling pathway; histone phosphorylation; negative regulation of cytokine production; negative regulation of transcription, DNA-dependent; positive regulation of histone acetylation; positive regulation of histone phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; regulation of transcription, DNA-dependent; stimulatory C-type lectin receptor signaling pathway
Reference #:  O75582 (UniProtKB)
Alt. Names/Synonyms: 90 kDa ribosomal protein S6 kinase 5; KS6A5; MGC1911; MSK1; MSPK1; Nuclear mitogen- and stress-activated protein kinase 1; Ribosomal protein S6 kinase alpha-5; ribosomal protein S6 kinase, 90kDa, polypeptide 5; RLPK; RPS6KA5; RSK-like protein kinase; RSKL; S6K-alpha-5
Gene Symbols: RPS6KA5
Molecular weight: 89,865 Da
Basal Isoelectric point: 6.63  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  NF-kB Signaling  |  Regulation of P38 MAPKs
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