Has guanine nucleotide-binding activity but weak intrinsic GTPase activity. Probably required for the amino acid- induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Forms a heterodimer with RRAGA in a sequence-independent manner. Binds GTP. Interacts with NOL8 and RRAGB. Belongs to the GTR/RAG GTP-binding protein family. Note: This description may include information from UniProtKB.
Molecular Function: GDP binding; GTP binding; GTPase activity; protein binding; protein heterodimerization activity
Biological Process: cell cycle arrest; cellular response to amino acid starvation; macroautophagy; positive regulation of TOR signaling pathway; regulation of autophagy; regulation of TOR signaling pathway; small GTPase mediated signal transduction
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.