Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
RRAGC (human)

Overview
RRAGC Has guanine nucleotide-binding activity but weak intrinsic GTPase activity. Probably required for the amino acid- induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Forms a heterodimer with RRAGA in a sequence-independent manner. Binds GTP. Interacts with NOL8 and RRAGB. Belongs to the GTR/RAG GTP-binding protein family. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 1p34
Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; lysosome; nucleus
Molecular Function: GDP binding; GTP binding; GTPase activity; protein binding; protein heterodimerization activity
Biological Process: cell cycle arrest; cellular response to amino acid starvation; macroautophagy; positive regulation of TOR signaling pathway; regulation of autophagy; regulation of TOR signaling pathway; response to amino acid stimulus; small GTPase mediated signal transduction
Reference #:  Q9HB90 (UniProtKB)
Alt. Names/Synonyms: FLJ13311; GTPase-interacting protein 2; GTR2; Rag C; Rag C protein; RagC; Ras-related GTP binding C; Ras-related GTP-binding protein C; RRAGC; TIB929
Gene Symbols: RRAGC
Molecular weight: 44,224 Da
Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states
CST Pathways:  mTOR Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RRAGC

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene