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Protein Page:
LYN (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
LYN a tyrosine kinase of the Src family that plays a role in B cell antigen-receptor signaling. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Oncoprotein; EC 2.7.10.2; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Src family
Chromosomal Location of Human Ortholog: 8q13
Cellular Component: cell-cell adherens junction; cytoplasm; cytosol; extrinsic to internal side of plasma membrane; Golgi apparatus; lipid raft; mast cell granule; mitochondrial crista; mitochondrial intermembrane space; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density
Molecular Function: ATP binding; enzyme binding; gamma-tubulin binding; glycosphingolipid binding; integrin binding; non-membrane spanning protein tyrosine kinase activity; phosphoprotein binding; platelet-derived growth factor receptor binding; protein binding; protein-tyrosine kinase activity; receptor binding; receptor signaling protein tyrosine kinase activity; SH3 domain binding; ubiquitin protein ligase binding
Biological Process: adaptive immune response; axon guidance; B cell homeostasis; B cell receptor signaling pathway; blood coagulation; cellular response to extracellular stimulus; cytokine secretion; ephrin receptor signaling pathway; erythrocyte differentiation; Fc receptor mediated inhibitory signaling pathway; Fc receptor mediated stimulatory signaling pathway; histamine secretion by mast cell; immune response-regulating cell surface receptor signaling pathway; innate immune response; leukocyte migration; lipopolysaccharide-mediated signaling pathway; negative regulation of B cell proliferation; negative regulation of cell proliferation; negative regulation of immune response; negative regulation of MAP kinase activity; negative regulation of myeloid leukocyte differentiation; negative regulation of protein amino acid phosphorylation; negative regulation of toll-like receptor 2 signaling pathway; negative regulation of toll-like receptor 4 signaling pathway; neurite development; oligodendrocyte development; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; positive regulation of B cell receptor signaling pathway; positive regulation of cell migration; positive regulation of cell motility; positive regulation of cell proliferation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of tyrosine phosphorylation of STAT protein; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of B cell apoptosis; regulation of B cell receptor signaling pathway; regulation of cell adhesion mediated by integrin; regulation of cytokine production; regulation of cytokine secretion; regulation of erythrocyte differentiation; regulation of inflammatory response; regulation of mast cell activation; regulation of mast cell degranulation; regulation of protein amino acid phosphorylation; regulation of release of sequestered calcium ion into cytosol; response to amino acid stimulus; response to axon injury; response to carbohydrate stimulus; response to DNA damage stimulus; response to drug; response to hormone stimulus; response to insulin stimulus; response to organic cyclic substance; response to sterol depletion; response to toxin; signal transduction; stimulatory C-type lectin receptor signaling pathway; T cell costimulation; tolerance induction to self antigen; transmembrane receptor protein tyrosine kinase signaling pathway; viral reproduction
Reference #:  P07948 (UniProtKB)
Alt. Names/Synonyms: FLJ26625; JTK8; LYN; Tyrosine-protein kinase Lyn; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Yamaguchi sarcoma viral (v-yes-1) related oncogene homolog
Gene Symbols: LYN
Molecular weight: 58,574 Da
Basal Isoelectric point: 6.7  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs  |  PI3K/Akt Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

LYN

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
cell growth, altered: Y397‑p
enzymatic activity, induced: Y397‑p
enzymatic activity, inhibited: Y508‑p

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 K9‑ub GCIKSKGkDsLsDDG
0 14 S11‑p IKSKGkDsLsDDGVD
0 33 S13‑p SKGkDsLsDDGVDLk
0 4 L19 LsDDGVDLkTQPVRN
0 15 K20‑ub sDDGVDLkTQPVRNT
1 103 Y32‑p RNTERTIyVRDPtSN
0 1 T37‑p TIyVRDPtSNKQQRP
0 1 T58‑p LPGQRFQtkDPEEQG
0 1 K59‑ub PGQRFQtkDPEEQGD
0 1 S115‑p KKEGFIPsNyVAKLN
0 4 Y117‑p EGFIPsNyVAKLNTL
0 1 T135‑p EWFFKDItRKDAERQ
0 1 S149‑p QLLAPGNsAGAFLIR
0 1 S158‑p GAFLIREsETLKGSF
0 1 K181 PVHGDVIKHYKIRSL
0 2 S187 IKHYKIRSLDNGGyy
0 777 Y193‑p RSLDNGGyyISPRIT
1 534 Y194‑p SLDNGGyyISPRITF
0 1 K213 DMIKHYQKQADGLCR
0 1 K213 DMIKHYQKQADGLCR
0 3 S228‑p RLEKACIsPKPQKPW
0 4 S246‑p AWEIPREsIKLVKRL
0 1 K248 EIPREsIKLVKRLGA
0 145 Y265‑p FGEVWMGyyNNsTKV
0 18 Y266‑p GEVWMGyyNNsTKVA
0 1 S269‑p WMGyyNNsTKVAVKt
0 1 T270 MGyyNNsTKVAVKtL
0 1 T276‑p sTKVAVKtLKPGtMs
0 1 T281‑p VKtLKPGtMsVQAFL
0 1 S283‑p tLKPGtMsVQAFLEE
0 1 T296‑p EEANLMKtLQHDKLV
0 127 Y306‑p HDKLVRLyAVVTREE
0 173 Y316‑p VTREEPIyIItEyMA
0 1 T319‑p EEPIyIItEyMAKGS
0 2 Y321‑p PIyIItEyMAKGSLL
17 2071 Y397‑p RVIEDNEytAREGAK
0 14 T398‑p VIEDNEytAREGAKF
0 1 T438‑p ILLYEIVtyGKIPYP
0 1 Y439‑p LLYEIVtyGKIPYPG
0 1 T448‑p KIPYPGRtNADVMTA
0 12 Y460‑p MTALSQGyRMPRVEN
0 728 Y473‑p ENCPDELyDIMkMCW
0 2 K477‑ub DELyDIMkMCWKEKA
0 1 T489 EKAEERPTFDYLQSV
0 3 Y501‑p QSVLDDFytAtEGQy
0 4 T502‑p SVLDDFytAtEGQyQ
0 9 T504‑p LDDFytAtEGQyQQQ
13 1578 Y508‑p ytAtEGQyQQQP___
  LYN iso2  
K9 GCIKSKGKDsLsDDG
S11‑p IKSKGKDsLsDDGVD
S13‑p SKGKDsLsDDGVDLk
L19 LsDDGVDLkTQPVPE
K20‑ub sDDGVDLkTQPVPES
- gap
- gap
T37 LPGQRFQTKDPEEQG
K38 PGQRFQTKDPEEQGD
S94 KKEGFIPSNYVAKLN
Y96 EGFIPSNYVAKLNTL
T114 EWFFKDITRKDAERQ
S128 QLLAPGNSAGAFLIR
S137 GAFLIRESETLKGSF
K160 PVHGDVIKHYKIRSL
S166 IKHYKIRSLDNGGyy
Y172‑p RSLDNGGyyISPRIT
Y173‑p SLDNGGyyISPRITF
K192 DMIKHYQKQADGLCR
K192 DMIKHYQKQADGLCR
S207 RLEKACISPKPQKPW
S225 AWEIPRESIKLVKRL
K227 EIPRESIKLVKRLGA
Y244 FGEVWMGYYNNSTKV
Y245 GEVWMGYYNNSTKVA
S248 WMGYYNNSTKVAVKT
T249 MGYYNNSTKVAVKTL
T255 STKVAVKTLKPGTMS
T260 VKTLKPGTMSVQAFL
S262 TLKPGTMSVQAFLEE
T275 EEANLMKTLQHDKLV
Y285 HDKLVRLYAVVTREE
Y295 VTREEPIYIITEYMA
T298 EEPIYIITEYMAKGS
Y300 PIYIITEYMAKGSLL
Y376‑p RVIEDNEyTAREGAK
T377 VIEDNEyTAREGAKF
T417 ILLYEIVTYGKIPYP
Y418 LLYEIVTYGKIPYPG
T427 KIPYPGRTNADVMTA
Y439 MTALSQGYRMPRVEN
Y452 ENCPDELYDIMKMCW
K456 DELYDIMKMCWKEKA
T468 EKAEERPTFDYLQSV
Y480 QSVLDDFYTATEGQy
T481 SVLDDFYTATEGQyQ
T483 LDDFYTATEGQyQQQ
Y487‑p YTATEGQyQQQP___
  mouse

► Hide Isoforms
 
K9‑ub GCIKSKRkDNLNDDE
N11 IKSKRkDNLNDDEVD
N13 SKRkDNLNDDEVDsk
S19‑p LNDDEVDskTQPVRN
K20‑ub NDDEVDskTQPVRNT
Y32‑p RNTDRTIyVRDPTSN
T37 TIyVRDPTSNKQQRP
T58 LPGQRFQTKDPEEQG
K59 PGQRFQTKDPEEQGD
S115 KREGFIPSNYVAKVN
Y117 EGFIPSNYVAKVNTL
T135 EWFFKDITRKDAERQ
S149 QLLAPGNSAGAFLIR
S158 GAFLIRESETLKGSF
K181 PMHGDVIKHYKIRsL
S187‑p IKHYKIRsLDNGGyy
Y193‑p RsLDNGGyyISPRIT
Y194‑p sLDNGGyyISPRITF
K213 DMIKHYQKQSDGLCR
K213‑ub DMIKHYQkQSDGLCR
S228 RLEKACISPKPQKPW
S246 AWEIPRESIKLVKKL
K248 EIPRESIKLVKKLGA
Y265‑p FGEVWMGyyNNStKV
Y266‑p GEVWMGyyNNStKVA
S269 WMGyyNNStKVAVKT
T270‑p MGyyNNStKVAVKTL
T276 StKVAVKTLKPGTMS
T281 VKTLKPGTMSVQAFL
S283 TLKPGTMSVQAFLEE
T296 EEANLMKTLQHDKLV
Y306 HDKLVRLYAVVTKEE
Y316‑p VTKEEPIyIITEFMA
T319 EEPIyIITEFMAKGS
F321 PIyIITEFMAKGSLL
Y397‑p RVIEDNEytAREGAK
T398‑p VIEDNEytAREGAKF
T438 ILLYEIVTYGKIPYP
Y439 LLYEIVTYGKIPYPG
T448 KIPYPGRTNADVMSA
Y460‑p MSALSQGyRMPRMEN
Y473‑p ENCPDELyDIMKMCW
K477 DELyDIMKMCWKEKA
T489‑p EKAEERPtFDYLQSV
Y501 QSVLDDFYtATEGQy
T502‑p SVLDDFYtATEGQyQ
T504 LDDFYtATEGQyQQQ
Y508‑p YtATEGQyQQQP___
2101 : Phospho-Src Family (Tyr416) Antibody
6943 : Phospho-Src Family (Tyr416) (D49G4) Rabbit mAb
2731 : Phospho-Lyn (Tyr507) Antibody
  LYN iso2  
K9 GCIKSKRKDNLNDDE
N11 IKSKRKDNLNDDEVD
N13 SKRKDNLNDDEVDsk
S19‑p LNDDEVDskTQPVPE
K20‑ub NDDEVDskTQPVPEF
- gap
- gap
T37 LPGQRFQTKDPEEQG
K38 PGQRFQTKDPEEQGD
S94 KREGFIPSNYVAKVN
Y96 EGFIPSNYVAKVNTL
T114 EWFFKDITRKDAERQ
S128 QLLAPGNSAGAFLIR
S137 GAFLIRESETLKGSF
K160 PMHGDVIKHYKIRSL
S166 IKHYKIRSLDNGGYY
Y172 RSLDNGGYYISPRIT
Y173 SLDNGGYYISPRITF
K192 DMIKHYQKQSDGLCR
K192 DMIKHYQKQSDGLCR
S207 RLEKACISPKPQKPW
S225 AWEIPRESIKLVKKL
K227 EIPRESIKLVKKLGA
Y244 FGEVWMGYYNNSTKV
Y245 GEVWMGYYNNSTKVA
S248 WMGYYNNSTKVAVKT
T249 MGYYNNSTKVAVKTL
T255 STKVAVKTLKPGTMS
T260 VKTLKPGTMSVQAFL
S262 TLKPGTMSVQAFLEE
T275 EEANLMKTLQHDKLV
Y285 HDKLVRLYAVVTKEE
Y295 VTKEEPIYIITEFMA
T298 EEPIYIITEFMAKGS
F300 PIYIITEFMAKGSLL
Y376 RVIEDNEYTAREGAK
T377 VIEDNEYTAREGAKF
T417 ILLYEIVTYGKIPYP
Y418 LLYEIVTYGKIPYPG
T427 KIPYPGRTNADVMSA
Y439 MSALSQGYRMPRMEN
Y452 ENCPDELYDIMKMCW
K456 DELYDIMKMCWKEKA
T468 EKAEERPTFDYLQSV
Y480 QSVLDDFYTATEGQY
T481 SVLDDFYTATEGQYQ
T483 LDDFYTATEGQYQQQ
Y487 YTATEGQYQQQP___
  rat

 
K9 GCIKSKRKDNLNDDG
N11 IKSKRKDNLNDDGVD
N13 SKRKDNLNDDGVDMK
M19 LNDDGVDMKTQPVRN
K20 NDDGVDMKTQPVRNT
Y32‑p RNTDRTIyVRDPTSN
T37 TIyVRDPTSNKQQRP
A58 LPGQRFQAKDPEEQG
K59 PGQRFQAKDPEEQGD
S115 KREGFIPSNYVAKVN
Y117 EGFIPSNYVAKVNTL
T135 EWFFKDITRKDAERQ
S149 QLLAPGNSAGAFLIR
S158 GAFLIRESETLKGSF
K181‑ac PMHGDVIkHYKIRSL
S187 IkHYKIRSLDNGGyy
Y193‑p RSLDNGGyyISPRIT
Y194‑p SLDNGGyyISPRITF
K213‑ac DMIKHYQkQSDGLCR
K213 DMIKHYQKQSDGLCR
S228 RLEKACISPKPQKPW
S246 AWEIPRESIkLVKKL
K248‑ac EIPRESIkLVKKLGA
Y265 FGEVWMGYYNNSTKV
Y266 GEVWMGYYNNSTKVA
S269 WMGYYNNSTKVAVKT
T270 MGYYNNSTKVAVKTL
T276 STKVAVKTLKPGTMS
T281 VKTLKPGTMSAQAFL
S283 TLKPGTMSAQAFLEE
T296 EEANLMKTLQHDKLV
Y306 HDKLVRLYAVVTKEE
Y316‑p VTKEEPIyIITEFMA
T319 EEPIyIITEFMAKGS
F321 PIyIITEFMAKGSLL
Y397‑p RVIEDNEyTAREGAK
T398 VIEDNEyTAREGAKF
T438 ILLYEIVTYGKIPYP
Y439 LLYEIVTYGKIPYPG
T448 KIPYPGRTNADVMTA
Y460 MTALSQGYRMPRMEN
Y473 ENCPDELYDIMKMCW
K477 DELYDIMKMCWKESA
T489 ESAEERPTFDYLQSV
Y501 QSVLDDFYTATEGQy
T502 SVLDDFYTATEGQyQ
T504 LDDFYTATEGQyQQQ
Y508‑p YTATEGQyQQQP___
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