Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element- specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: actin cytoskeleton; actin filament; cell cortex; cortical actin cytoskeleton; cytoplasm; cytosol; membrane; perinuclear region of cytoplasm
Molecular Function: MAP-kinase scaffold activity; protein complex scaffold; protein kinase A binding; Rho GTPase binding; Rho guanyl-nucleotide exchange factor activity
Biological Process: cardiac muscle cell differentiation; G-protein coupled receptor protein signaling pathway; heart development; nuclear export; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of Rho protein signal transduction; regulation of protein kinase activity
Alt. Names/Synonyms: 1700026G02Rik; 5730522G15Rik; 5830460E08Rik; A kinase (PRKA) anchor protein 13; AKAP-Lbc; Akap13; AKP13; BRX; Ht31; LBC; PROTO-LB; PROTO-LBC; type II cAMP-dependent protein kinase anchoring protein Ht31