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Protein Page:
AKAP13 (mouse)

Overview
AKAP13 Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element- specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; GEFs; GEFs, Rac/Rho; Nuclear export; Nuclear receptor co-regulator; Oncoprotein
Cellular Component: actin cytoskeleton; actin filament; cell cortex; cortical actin cytoskeleton; cytoplasm; cytosol; membrane; perinuclear region of cytoplasm
Molecular Function: MAP-kinase scaffold activity; protein complex scaffold; protein kinase A binding; Rho GTPase binding; Rho guanyl-nucleotide exchange factor activity
Biological Process: cardiac muscle cell differentiation; G-protein coupled receptor protein signaling pathway; heart development; nuclear export; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of Rho protein signal transduction; regulation of protein kinase activity
Reference #:  E9Q394 (UniProtKB)
Alt. Names/Synonyms: 1700026G02Rik; 5730522G15Rik; 5830460E08Rik; A kinase (PRKA) anchor protein 13; AKAP-Lbc; Akap13; AKP13; BRX; Ht31; LBC; PROTO-LB; PROTO-LBC; type II cAMP-dependent protein kinase anchoring protein Ht31
Gene Symbols: Akap13
Molecular weight: 303,976 Da
Basal Isoelectric point: 5.26  Predict pI for various phosphorylation states
Select Structure to View Below

AKAP13

Protein Structure Not Found.
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