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Protein Page:
CHD-3 iso3 (human)

Overview
CHD-3 iso3 Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressive complex. Interacts with TRIM28 and SERBP1. Interacts (via its C-terminal) with HABP4. Interacts with PCNT; the interaction regulates centrosome integrity. Widely expressed. Belongs to the SNF2/RAD54 helicase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; EC 3.6.4.12; Helicase
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: centrosome; cytoplasm; intermediate filament cytoskeleton; nucleolus; nucleoplasm; nucleus; NuRD complex
Molecular Function: ATP-dependent DNA helicase activity; histone deacetylase activity; protein binding
Biological Process: centrosome organization and biogenesis; regulation of transcription from RNA polymerase II promoter; spindle organization and biogenesis
Reference #:  Q12873-3 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent helicase CHD3; CHD-3; CHD3; chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3; hZFH; Mi-2 autoantigen 240 kDa protein; Mi-2a; Mi2-alpha; ZFH; Zinc finger helicase; zinc-finger helicase (Snf2-like)
Gene Symbols: CHD3
Molecular weight: 233,037 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CHD-3 iso3

Protein Structure Not Found.


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