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Protein Page:
TACC3 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TACC3 Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. May be involved in the control of cell growth and differentiation. May contribute to cancer. Interacts with microtubules. Interacts with CCDC100/CEP120. The coiled coil C-terminus region interacts with AH receptor nuclear translocator protein (ARNT) and ARNT2. Interacts with GCN5L2 and PCAF. Up-regulated in various cancer cell lines. Belongs to the TACC family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 4p16.3
Cellular Component: cytoplasm; microtubule cytoskeleton
Molecular Function: protein binding; protein domain specific binding
Biological Process: astral microtubule organization and biogenesis; cell proliferation; cerebral cortex development; cytoplasmic sequestering of transcription factor; hemopoiesis; interkinetic nuclear migration; microtubule cytoskeleton organization and biogenesis; neurogenesis; regulation of cell cycle; regulation of microtubule-based process; response to hypoxia
Disease: Bladder Cancer
Reference #:  Q9Y6A5 (UniProtKB)
Alt. Names/Synonyms: ERIC-1; ERIC1; MGC117382; MGC133242; TACC3; Transforming acidic coiled-coil-containing protein 3; transforming, acidic coiled-coil containing protein 3
Gene Symbols: TACC3
Molecular weight: 90,360 Da
Basal Isoelectric point: 4.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TACC3

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S558‑p

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S12‑p VLNDKNVsNEKNTEN
0 13 S25‑p ENCDFLFsPPEVtGR
0 1 T30‑p LFsPPEVtGRSSVLR
1 0 S34 PEVtGRSSVLRVsQK
0 16 S39‑p RSSVLRVsQKENVPP
0 1 K51‑m3 VPPKNLAkAMkVtFQ
0 1 K54‑m3 KNLAkAMkVtFQtPL
0 6 T56‑p LAkAMkVtFQtPLRD
0 64 T59‑p AMkVtFQtPLRDPQt
0 1 T66‑p tPLRDPQtHRILsPs
0 17 S71‑p PQtHRILsPsMASKL
0 1 S73‑p tHRILsPsMASKLEA
0 2 S170‑p SSENQMVsPGKVsGs
0 3 S175‑p MVsPGKVsGsPEQAV
0 6 S177‑p sPGKVsGsPEQAVEE
0 1 S187‑p QAVEENLsSYSLDRR
0 1 T196‑p YSLDRRVtPASETLE
0 3 T216‑p ESQHKAEtPHGAEEE
0 4 T228‑p EEECKAEtPHGAEEE
0 1 T249‑p CAPAAVAtsPPGAIP
0 18 S250‑p APAAVAtsPPGAIPK
0 8 T315‑p LVAGRAMtLsPQEEV
0 19 S317‑p AGRAMtLsPQEEVAA
0 4 S402‑p PMPASRGsyHLDWDK
0 1 Y403‑p MPASRGsyHLDWDKM
0 1 K423‑ac IPFGGDTkSGCSEAQ
0 19 S434‑p SEAQPPEsPEtRLGQ
0 2 T437‑p QPPEsPEtRLGQPAA
0 2 T481‑p VVQLAAEtPTAESKE
0 1 T496‑p RALNSAStSLPTSCP
0 1 S505‑p LPTSCPGsEPVPTHQ
0 1 S524‑p ALELKEEsFRDPAEV
0 1 T534‑p DPAEVLGtGAEVDyL
0 8 Y540‑p GtGAEVDyLEQFGTS
0 1 K550‑ub QFGTSSFkESALRKQ
1 0 S552 GTSSFkESALRKQsL
8 39 S558‑p ESALRKQsLyLkFDP
0 28 Y560‑p ALRKQsLyLkFDPLL
0 2 K562‑ub RKQsLyLkFDPLLRD
0 4 S570‑p FDPLLRDsPGRPVPV
0 3 T590‑p SMHGANEtPsGRPRE
0 1 S592‑p HGANEtPsGRPREAK
0 16 K649‑ub KDLDAVVkATQEENR
0 1 C662 NRELRSRCEELHGKN
0 2 K674‑ub GKNLELGkIMDRFEE
0 7 Y684‑p DRFEEVVyQAMEEVQ
0 1 K720 TDLNSMEKSFsDLFK
0 2 S723‑p NSMEKSFsDLFKRFE
0 1 K731 DLFKRFEKQKEVIEG
0 1 Y739‑p QKEVIEGyRKNEESL
0 1 K741 EVIEGyRKNEESLKK
0 2 S799‑p EALALQAsLRKEQMR
0 1 K819‑ub KTVEQKTkENEELTR
0 2 K834‑ub ICDDLISkMEKI___
5645 : Phospho-TACC3 (Ser558) Antibody
8842 : Phospho-TACC3 (Ser558) (D8H10) XP(R) Rabbit mAb
  mouse

 
P12 VLNDENVPNEKSSQC
L25 QCRDFQFLPPELTGR
T30 QFLPPELTGRSSVLC
S34 PELTGRSSVLCLSQK
S39 RSSVLCLSQKENVPP
K51 VPPQSQAKATNVTFQ
N54 QSQAKATNVTFQtPP
T56 QAKATNVTFQtPPRD
T59‑p ATNVTFQtPPRDPQT
T66 tPPRDPQTHRILsPN
S71‑p PQTHRILsPNMTNKR
N73 THRILsPNMTNKREA
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S285 GLEPVLDSELVTPPI
- gap
S313 VVDLKEESFRDPSEV
T323 DPSEVLGTGAEVDYL
Y329 GTGAEVDYLEQFGTS
K339 QFGTSSFKESAWRKQ
S341 GTSSFKESAWRKQsL
S347‑p ESAWRKQsLYVKFDP
Y349 AWRKQsLYVKFDPLL
K351 RKQsLYVKFDPLLKD
S359 FDPLLKDSPLRPMPV
S380 TQDTEEESGSGKPTE
S382 DTEEESGSGKPTEAE
N439 KDLDAVVNVMQQENL
Y452‑p NLELKSKyEDLNTKY
K464 TKYLEMGKSVDEFEK
Y474 DEFEKIAYKSLEEAE
K513‑ac ADLNSMEkSFsDLFK
S516‑p NSMEkSFsDLFKRFE
K524‑ac DLFKRFEkRKEVIEG
Y532 RKEVIEGYQkNEESL
K534‑ac EVIEGYQkNEESLKK
S592‑p EVLALQAsLRKAQMQ
K612 MTLEQKTKEIDELTR
K627 ICDDLISKMEKI___
  pig

 
T12 VFSDENVTGDRSTEN
S25 ENCDFLFSPLELTGR
T30 LFSPLELTGRSSVLR
S34 LELTGRSSVLRLSQK
S39 RSSVLRLSQKENVPP
K51 VPPKSTAKATKVTFQ
K54 KSTAKATKVTFQTPL
T56 TAKATKVTFQTPLRD
T59 ATKVTFQTPLRDPQT
T66 TPLRDPQTHRILSPS
S71 PQTHRILSPSMGSKL
S73 THRILSPSMGSKLDA
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
T386 GLQPMAGTPGATGEE
T401 GATDASGTPAPTSSP
- gap
Q426 APDLSGEQFRDPADV
T436 DPADVLGTGAEVDYL
Y442 GTGAEVDYLEQFGAS
K452 QFGASSFKDSALRKQ
S454 GASSFKDSALRKQsL
S460‑p DSALRKQsLYLKFDP
Y462 ALRKQsLYLKFDPLL
K464 RKQsLYLKFDPLLQD
S472 FDPLLQDSPRRPAPT
S493 ACGMDAPSSGSAPEA
S494 CGMDAPSSGSAPEAA
E551 RDLDAAVEATQKENA
C564 NAELRSRCTELQEKV
K576 EKVLEMGKIMDRFEE
Y586 DRFEETVYQAMEEAQ
K622 GDLRSVEKSFSELFR
S625 RSVEKSFSELFRRFE
K633 ELFRRFEKQKEVIEG
Y641 QKEVIEGYRTNEASL
T643 EVIEGYRTNEASLKK
V701 EVLALQAVLKKEQMR
K721 KAMEQKTKENDELTR
K736 ICDDLISKMERI___
  chicken

 
S15 AENGENVSDDLTAEE
A28 EECGFYFALPEPTER
T33 YFALPEPTERPsILR
S37‑p PEPTERPsILRLSQK
S42 RPsILRLSQKENLPP
K54 LPPKSVAKAMKVTFQ
K57 KSVAKAMKVTFQTPL
T59 VAKAMKVTFQTPLRD
T62 AMKVTFQTPLRDPQS
S69 TPLRDPQSRKILSPT
S74 PQSRKILSPTMTDKL
T76 SRKILSPTMTDKLDS
S173 SPGNLQKSPVRVSSS
S178 QKSPVRVSSSPEKTS
S180 SPVRVSSSPEKTSEE
S188 PEKTSEESSNSLPLD
S199 LPLDNTASPSTTAST
- gap
- gap
S229 SVLLELESNKPDLFP
N230 VLLELESNKPDLFPK
- gap
- gap
S377 EAPVPRASYKFDWDK
Y378 APVPRASYKFDWDKL
K398 NPFGGGSKISTSPKC
- gap
- gap
- gap
M493 KQISPSKMSPANVPS
S523 AEEIKPTSHKNEITA
L542 ASTEPEELFRPSAEV
M552 PSAEVLGMGIDYLEQ
Y556 VLGMGIDYLEQFGTS
K566 QFGTSSFKEsALRKQ
S568‑p GTSSFKEsALRKQsL
S574‑p EsALRKQsLYLKFDP
Y576 ALRKQsLYLKFDPLL
K578 RKQsLYLKFDPLLRD
S586 FDPLLRDSPRKQPIF
T626 LEETEKPTSSLQNEE
S627 EETEKPTSSLQNEEK
E693 KDMDAAVELVKREVQ
Y713 ALEWKKKYNKLHMEY
K725 MEYKEMGKVVAEFEG
T735 AEFEGTITQMMEDSQ
K771 SDLNSMEKSFSELFK
S774 NSMEKSFSELFKRFE
K782 ELFKRFEKQKEVLEG
Y790 QKEVLEGYRKNEEAL
K792 EVLEGYRKNEEALKK
S850 ETAALQASLRKEQMR
K870 RSLEQKTKENDELTK
K885 ICDDLILKMGKNG__
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