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Protein Page:
WSTF (human)

Overview
WSTF plays a central role in chromatin remodeling and acts as a transcription regulator. Apparently possesses tyrosine-protein kinase activity, but bears no sequence resemblance classical tyrosine kinase proteins. Involved in DNA damage response by phosphorylating Y142 of histone H2AX. H2AXpY142 plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at Y142, and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. In the WINAC complex, plays an essential role by targeting the complex to acetylated histones, an essential step for VDR-promoter association. Accumulates in pericentromeric heterochromatin during replication. Targeted to replication foci throughout S phase via its association with PCNA. Ubiquitously expressed with high levels of expression in heart, brain, placenta, skeletal muscle and ovary. Two alternatively-spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; BAZ family; DNA replication; EC 2.7.10.2; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: nuclear replication fork; nucleoplasm
Molecular Function: chromatin binding; histone kinase activity; protein binding; protein-tyrosine kinase activity
Biological Process: chromatin-mediated maintenance of transcription; double-strand break repair; heart morphogenesis; histone phosphorylation; positive regulation of gene expression, epigenetic; regulation of transcription, DNA-dependent; response to DNA damage stimulus
Reference #:  Q9UIG0 (UniProtKB)
Alt. Names/Synonyms: BAZ1B; Bromodomain adjacent to zinc finger domain protein 1B; bromodomain adjacent to zinc finger domain, 1B; hWALp2; transcription factor WSTF; Tyrosine-protein kinase BAZ1B; WBSC10; WBSCR10; WBSCR9; Williams syndrome transcription factor; Williams-Beuren syndrome chromosomal region 10 protein; Williams-Beuren syndrome chromosomal region 9 protein; Williams-Beuren syndrome chromosome region 10; Williams-Beuren syndrome chromosome region 9; WSTF
Gene Symbols: BAZ1B
Molecular weight: 170,903 Da
Basal Isoelectric point: 8.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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WSTF

Protein Structure Not Found.
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