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Protein Page:
FGFR1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FGFR1 a receptor tyrosine kinase of the highly-conserved fibroblast growth factor receptor (FGFR). Binds both acidic and basic fibroblast growth factors and is involved in limb induction. Point mutations cause Pfeffer syndrome (finger and toe malformations and other skeletal errors) and dominant Kallmann syndrome 2. Stem cell leukemia lymphoma syndrome (SCLL) may be caused by a t(8;13)(p12;q12) translocation that fuses a zinc finger gene, ZNF198, to FGFR1. Various myeloproliferative disorders have been linked to translocations that fuse FGFR1 to FOP, FIM, CEP1 or the atypical kinase, Bcr. Inhibitor: SU5402. 20 isoforms of the human protein produced by alternative splicing have been described. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Kinase, protein; Oncoprotein; Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; FGFR family
Chromosomal Location of Human Ortholog: 8p11.23-p11.22
Cellular Component: integral to plasma membrane; plasma membrane; receptor complex
Molecular Function: 1-phosphatidylinositol-3-kinase activity; fibroblast growth factor binding; fibroblast growth factor receptor activity; heparin binding; identical protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein homodimerization activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity
Biological Process: cell migration; chordate embryonic development; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; neuron migration; peptidyl-tyrosine phosphorylation; phosphoinositide-mediated signaling; positive regulation of cell proliferation; positive regulation of MAP kinase activity; positive regulation of MAPKKK cascade; positive regulation of neuron differentiation; positive regulation of phosphoinositide 3-kinase cascade; protein amino acid autophosphorylation; regulation of cell differentiation; regulation of phosphoinositide 3-kinase cascade; skeletal development; skeletal morphogenesis
Disease: Hypogonadotropic Hypogonadism 2 With Or Without Anosmia; Jackson-weiss Syndrome; Osteoglophonic Dysplasia; Pfeiffer Syndrome; Trigonocephaly 1
Reference #:  P11362 (UniProtKB)
Alt. Names/Synonyms: Basic fibroblast growth factor receptor 1; bFGF-R-1; BFGFR; CD331; CEK; FGFBR; FGFR-1; FGFR1; fibroblast growth factor receptor 1; FLG; FLJ99988; FLT-2; FLT2; Fms-like tyrosine kinase 2; fms-related tyrosine kinase 2; HBGFR; heparin-binding growth factor receptor; KAL2; N-SAM; OGD; Proto-oncogene c-Fgr; soluble FGFR1 variant 1; soluble FGFR1 variant 2
Gene Symbols: FGFR1
Molecular weight: 91,868 Da
Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  ESC Pluripotency and Differentiation  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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FGFR1

Protein Structure Not Found.
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Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
apoptosis, inhibited: S779‑p
cell cycle regulation: Y463‑p, Y730‑p
cell differentiation, altered: Y653‑p, Y654‑p
cell differentiation, induced: S779‑p
cell growth, altered: Y463‑p, Y653‑p, Y654‑p
cell growth, inhibited: S777‑p
cell motility, altered: Y653‑p, Y654‑p
cell motility, inhibited: S777‑p
cytoskeletal reorganization: Y154‑p
transcription, altered: Y463‑p, Y730‑p
enzymatic activity, induced: Y653‑p, Y654‑p
intracellular localization: S777‑p
molecular association, regulation: Y463‑p, Y677‑p, Y766‑p
phosphorylation: Y653‑p, Y654‑p
protein degradation: Y154‑p
receptor desensitization, altered: Y154‑p
receptor internalization, altered: Y154‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S76 DGVQLAESNRTRITG
0 1 S91‑p EEVEVQDsVPADSGL
2 1 Y154‑p NRMPVAPyWTSPEKM
0 1 K164‑ac SPEKMEKkLHAVPAA
0 1 K172‑ac LHAVPAAkTVKFKCP
0 1 S180 TVKFKCPSSGTPNPT
0 1 K198 LKNGKEFKPDHRIGG
1 1 Y210‑p IGGYKVRyATWSIIM
1 1 Y280‑p VEFMCKVySDPQPHI
1 1 Y307‑p IGPDNLPyVQILKTA
0 1 T403‑p VYKMKSGtKKSDFHs
0 1 S410‑p tKKSDFHsQMAVHKL
0 7 T428‑p IPLRRQVtVSADSSA
0 1 S439‑p DSSASMNsGVLLVRP
0 2 S447‑p GVLLVRPsRLsssGt
0 10 S450‑p LVRPsRLsssGtPML
0 8 S451‑p VRPsRLsssGtPMLA
0 4 S452‑p RPsRLsssGtPMLAG
0 1 T454‑p sRLsssGtPMLAGVS
6 11 Y463‑p MLAGVSEyELPEDPR
0 1 K482‑ub RDRLVLGkPLGEGCF
0 2 Y572‑p SKGNLREyLQARRPP
4 66 Y583‑p RRPPGLEyCyNPsHN
4 43 Y585‑p PPGLEyCyNPsHNPE
0 2 S588‑p LEyCyNPsHNPEEQL
1 13 Y605‑p KDLVSCAyQVARGME
0 6 Y613‑p QVARGMEyLASKKCI
0 1 K638‑ub VTEDNVMkIADFGLA
10 331 Y653‑p RDIHHIDyyKKTTNG
10 185 Y654‑p DIHHIDyyKKTTNGR
2 0 Y677‑p EALFDRIyTHQSDVW
1 0 Y701 FTLGGSPYPGVPVEE
5 2 Y730‑p SNCTNELyMMMRDCW
0 2 K748‑ub PSQRPTFkQLVEDLD
8 0 Y766‑p ALTSNQEyLDLSMPL
2 3 Y776‑p LSMPLDQysPsFPDT
3 0 S777‑p SMPLDQysPsFPDTR
1 0 S779‑p PLDQysPsFPDTRSS
1 1 S789‑p DTRSSTCsSGEDSVF
0 1 S790 TRSSTCsSGEDSVFS
0 1 G817 HPAQLANGGLKRR__
3471 : Phospho-FGF Receptor (Tyr653/654) Antibody
3476 : Phospho-FGF Receptor (Tyr653/654) (55H2) Mouse mAb
3471 : Phospho-FGF Receptor (Tyr653/654) Antibody
3476 : Phospho-FGF Receptor (Tyr653/654) (55H2) Mouse mAb
2544 : Phospho-FGF Receptor 1 (Tyr766) (1E5) Rabbit mAb
  FGFR1 iso2  
S76 DGVQLAESNRTRITG
S91 EEVEVQDSVPADSGL
Y154 NRMPVAPYWTSPEKM
K164 SPEKMEKKLHAVPAA
K172 LHAVPAAKTVKFKCP
S180 TVKFKCPSSGTPNPT
K198 LKNGKEFKPDHRIGG
Y210 IGGYKVRYATWSIIM
Y280 VEFMCKVYSDPQPHI
Y307 IGPDNLPYVQILKTA
T403 VYKMKSGTKKSDFHS
S410 TKKSDFHSQMAVHKL
- gap
S437 DSSASMNSGVLLVRP
S445 GVLLVRPSRLSSSGT
S448 LVRPSRLSSSGTPML
S449 VRPSRLSSSGTPMLA
S450 RPSRLSSSGTPMLAG
T452 SRLSSSGTPMLAGVS
Y461 MLAGVSEYELPEDPR
K480 RDRLVLGKPLGEGCF
Y570 SKGNLREYLQARRPP
Y581 RRPPGLEYCYNPSHN
Y583 PPGLEYCYNPSHNPE
S586 LEYCYNPSHNPEEQL
Y603 KDLVSCAYQVARGME
Y611 QVARGMEYLASKKCI
K636 VTEDNVMKIADFGLA
Y651 RDIHHIDYYKKTTNG
Y652 DIHHIDYYKKTTNGR
Y675 EALFDRIYTHQSDVW
Y699 FTLGGSPYPGVPVEE
Y728 SNCTNELYMMMRDCW
K746 PSQRPTFKQLVEDLD
Y764 ALTSNQEYLDLSMPL
Y774 LSMPLDQYSPSFPDT
S775 SMPLDQYSPSFPDTR
S777 PLDQYSPSFPDTRSS
S787 DTRSSTCSSGEDSVF
S788 TRSSTCSSGEDSVFS
G815 HPAQLANGGLKRR__
  FGFR1 iso14  
- gap
- gap
Y63 KPNPVAPYWTSPEKM
K73 SPEKMEKKLHAVPAA
K81 LHAVPAAKTVKFKCP
S89 TVKFKCPSSGTPNPT
K107 LKNGKEFKPDHRIGG
Y119 IGGYKVRYATWSIIM
Y189 VEFMCKVYSDPQPHI
Y216 IGPDNLPYVQILKTA
T312 VYKMKSGTKKSDFHS
S319 TKKSDFHSQMAVHKL
T337 IPLRRQVTVSADSSA
S348 DSSASMNSGVLLVRP
S356 GVLLVRPSRLSSSGT
S359 LVRPSRLSSSGTPML
S360 VRPSRLSSSGTPMLA
S361 RPSRLSSSGTPMLAG
T363 SRLSSSGTPMLAGVS
Y372 MLAGVSEYELPEDPR
K391 RDRLVLGKPLGEGCF
Y481 SKGNLREYLQARRPP
Y492 RRPPGLEYCYNPSHN
Y494 PPGLEYCYNPSHNPE
S497 LEYCYNPSHNPEEQL
Y514 KDLVSCAYQVARGME
Y522 QVARGMEYLASKKCI
K547 VTEDNVMKIADFGLA
Y562 RDIHHIDYYKKTTNG
Y563 DIHHIDYYKKTTNGR
Y586 EALFDRIYTHQSDVW
Y610 FTLGGSPYPGVPVEE
Y639 SNCTNELYMMMRDCW
K657 PSQRPTFKQLVEDLD
Y675 ALTSNQEYLDLSMPL
Y685 LSMPLDQYSPSFPDT
S686 SMPLDQYSPSFPDTR
S688 PLDQYSPSFPDTRSS
S698 DTRSSTCSSGEDSVF
S699 TRSSTCSSGEDSVFS
G726 HPAQLANGGLKRR__
  FGFR1 iso21  
S109 DGVQLAESNRTRITG
S124 EEVEVQDSVPADSGL
Y185 KPNPVAPYWTSPEKM
K195 SPEKMEKKLHAVPAA
K203 LHAVPAAKTVKFKCP
S211 TVKFKCPSSGTPNPT
K229 LKNGKEFKPDHRIGG
Y241 IGGYKVRYATWSIIM
Y311 VEFMCKVYSDPQPHI
Y338 IGPDNLPYVQILKTA
T434 VYKMKSGTKKSDFHS
S441 TKKSDFHSQMAVHKL
T459 IPLRRQVTVSADSSA
S470 DSSASMNSGVLLVRP
S478 GVLLVRPSRLSSSGT
S481 LVRPSRLSSSGTPML
S482 VRPSRLSSSGTPMLA
S483 RPSRLSSSGTPMLAG
T485 SRLSSSGTPMLAGVS
Y494 MLAGVSEYELPEDPR
K513 RDRLVLGKPLGEGCF
Y603 SKGNLREYLQARRPP
Y614 RRPPGLEYCYNPSHN
Y616 PPGLEYCYNPSHNPE
S619 LEYCYNPSHNPEEQL
Y636 KDLVSCAYQVARGME
Y644 QVARGMEYLASKKCI
K669 VTEDNVMKIADFGLA
Y684 RDIHHIDYYKKTTNG
Y685 DIHHIDYYKKTTNGR
Y708 EALFDRIYTHQSDVW
Y732 FTLGGSPYPGVPVEE
Y761 SNCTNELYMMMRDCW
K779 PSQRPTFKQLVEDLD
Y797 ALTSNQEYLDLSMPL
Y807 LSMPLDQYSPSFPDT
S808 SMPLDQYSPSFPDTR
S810 PLDQYSPSFPDTRSS
S820 DTRSSTCSSGEDSVF
S821 TRSSTCSSGEDSVFS
G848 HPAQLANGGLKRR__
  mouse

 
S76‑p DGVQLVEsNRTRITG
S91 EEVEVRDSIPADSGL
Y154 NRRPVAPYWTSPEKM
K164 SPEKMEKKLHAVPAA
K172 LHAVPAAKTVKFKCP
S180‑p TVKFKCPsSGTPNPT
K198‑ub LKNGKEFkPDHRIGG
Y210 IGGYKVRYATWSIIM
Y280 VEFMCKVYSDPQPHI
Y307 IGPDNLPYVQILKTA
T403 IYKMKSGTKKSDFHS
S410 TKKSDFHSQMAVHKL
T428 IPLRRQVTVSADSSA
S439 DSSASMNSGVLLVRP
S447 GVLLVRPSRLssSGT
S450‑p LVRPSRLssSGTPML
S451‑p VRPSRLssSGTPMLA
S452 RPSRLssSGTPMLAG
T454 SRLssSGTPMLAGVS
Y463 MLAGVSEYELPEDPR
K482 RDRLVLGKPLGEGCF
Y572 SKGNLREYLQARRPP
Y583‑p RRPPGLEyCyNPSHN
Y585‑p PPGLEyCyNPSHNPE
S588 LEyCyNPSHNPEEQL
Y605‑p KDLVSCAyQVARGME
Y613‑p QVARGMEyLASKKCI
K638 VTEDNVMKIADFGLA
Y653‑p RDIHHIDyyKKTTNG
Y654‑p DIHHIDyyKKTTNGR
Y677 EALFDRIYTHQSDVW
Y701 FTLGGSPYPGVPVEE
Y730 SNCTNELYMMMRDCW
K748 PSQRPTFKQLVEDLD
Y766‑p ALTSNQEyLDLSIPL
Y776 LSIPLDQYSPSFPDT
S777 SIPLDQYSPSFPDTR
S779 PLDQYSPSFPDTRSS
S789‑p DTRSSTCssGEDSVF
S790‑p TRSSTCssGEDSVFS
S817‑p HPTQLANsGLKRR__
3471 : Phospho-FGF Receptor (Tyr653/654) Antibody
3476 : Phospho-FGF Receptor (Tyr653/654) (55H2) Mouse mAb
3471 : Phospho-FGF Receptor (Tyr653/654) Antibody
3476 : Phospho-FGF Receptor (Tyr653/654) (55H2) Mouse mAb
  rat

► Hide Isoforms
 
- gap
- gap
Y63 KPNPVAPYWTSPEKM
K73 SPEKMEKKLHAVPAA
K81 LHAVPAAKTVKFKCP
S89 TVKFKCPSSGTPSPT
K107 LKNGKEFKPDHRIGG
Y119 IGGYKVRYATWSIIM
Y189 VEFMCKVYSDPQPHI
Y216 IGPDNLPYVQILKTA
T312 IYKMKSGTKKSDFHS
S319 TKKSDFHSQMAVHKL
- gap
S346 DSSASMNSGVLLVRP
S354 GVLLVRPSRLSSSGT
S357 LVRPSRLSSSGTPML
S358 VRPSRLSSSGTPMLA
S359 RPSRLSSSGTPMLAG
T361 SRLSSSGTPMLAGVS
Y370 MLAGVSEYELPEDPR
K389 RDRLVLGKPLGEGCF
Y479 SKGNLREYLQARRPP
Y490 RRPPGLEYCYNPSHN
Y492 PPGLEYCYNPSHNPE
S495 LEYCYNPSHNPEEQL
Y512 KDLVSCAYQVARGME
Y520 QVARGMEYLASKKCI
K545 VTEDNVMKIADFGLA
Y560‑p RDIHHIDyyKKTTNG
Y561‑p DIHHIDyyKKTTNGR
Y584‑p EALFDRIyTHQSDVW
Y608‑p FTLGGSPyPGVPVEE
Y637‑p SNCTNELyMMMRDCW
K655 PSQRPTFKQLVEDLD
Y673‑p ALTSNQEyLDLSMPL
Y683‑p LSMPLDQySPSFPDT
S684 SMPLDQySPSFPDTR
S686 PLDQySPSFPDTRSS
S696 DTRSSTCSSGEDSVF
S697 TRSSTCSSGEDSVFS
G724 HPTQLANGGLKRR__
3471 : Phospho-FGF Receptor (Tyr653/654) Antibody
3476 : Phospho-FGF Receptor (Tyr653/654) (55H2) Mouse mAb
3471 : Phospho-FGF Receptor (Tyr653/654) Antibody
3476 : Phospho-FGF Receptor (Tyr653/654) (55H2) Mouse mAb
  FGFR1 iso2  
S76 DGVQLAESNRTRITG
S91 EEVEVRDSIPADSGL
Y154 NRRPVAPYWTSPEKM
K164 SPEKMEKKLHAVPAA
K172 LHAVPAAKTVKFKCP
S180 TVKFKCPSSGTPSPT
K198 LKNGKEFKPDHRIGG
Y210 IGGYKVRYATWSIIM
Y280 VEFMCKVYSDPQPHI
Y307 IGPDNLPYDQILKTA
T403 IYKMKSGTKKSDFHS
S410 TKKSDFHSQMAVHKL
T428 IPLRRQVTVSADSSA
S439 DSSASMNSGVLLVRP
S447 GVLLVRPSRLSSSGT
S450 LVRPSRLSSSGTPML
S451 VRPSRLSSSGTPMLA
S452 RPSRLSSSGTPMLAG
T454 SRLSSSGTPMLAGVS
Y463 MLAGVSEYELPEDPR
K482 RDRLVLGKPLGEGCF
Y572 SKGNLREYLQARRPP
Y583 RRPPGLEYCYNPSHN
Y585 PPGLEYCYNPSHNPE
S588 LEYCYNPSHNPEEQL
Y605 KDLVSCAYQVARGME
Y613 QVARGMEYLASKKCI
K638 VTEDNVMKIADFGLA
Y653 RDIHHIDYYKKTTNG
Y654 DIHHIDYYKKTTNGR
Y677 EALFDRIYTHQSDVW
N701 FTLGGSPNPGVPVEE
Y730 SNCTNELYMMMRDCW
K748 PSQRPTFKQLVEDLD
Y766 ALTSNQEYLDLSMPL
D776 LSMPLDQDSPSFPDT
S777 SMPLDQDSPSFPDTR
S779 PLDQDSPSFPDTRSS
S789 DTRSSTCSSGEDSVF
S790 TRSSTCSSGEDSVFS
G817 HPTQLANGGLNRR__
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