Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
SMC4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SMC4 Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Forms an heterodimer with SMC2. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG. Widely expressed. Higher expression in testis, colon, thymus. Belongs to the SMC family. SMC4 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 3q26.1
Cellular Component: condensin complex; cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: ATP binding; protein binding; protein heterodimerization activity
Biological Process: cell division; kinetochore organization and biogenesis; meiotic chromosome condensation; meiotic chromosome segregation; mitotic cell cycle; mitotic chromosome condensation; mitotic sister chromatid segregation
Reference #:  Q9NTJ3 (UniProtKB)
Alt. Names/Synonyms: CAPC; Chromosome-associated polypeptide C; hCAP-C; SMC protein 4; SMC-4; SMC4; SMC4 structural maintenance of chromosomes 4-like 1; SMC4L1; structural maintenance of chromosomes 4; Structural maintenance of chromosomes protein 4; XCAP-C homolog
Gene Symbols: SMC4
Molecular weight: 147,182 Da
Basal Isoelectric point: 6.37  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SMC4

Protein Structure Not Found.


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 34 S22‑p EEGPPPPsPDGAssD
0 16 S27‑p PPsPDGAssDAEPEP
0 27 S28‑p PsPDGAssDAEPEPP
0 1 S36‑p DAEPEPPsGRtEsPA
0 17 T39‑p PEPPsGRtEsPAtAA
0 32 S41‑p PPsGRtEsPAtAAEt
0 9 T44‑p GRtEsPAtAAEtAsE
0 2 T48‑p sPAtAAEtAsEELDN
0 5 S50‑p AtAAEtAsEELDNRS
0 1 T85‑p GAPRLMItHIVNQNF
0 1 K93‑ub HIVNQNFkSYAGEkI
0 1 K99‑ub FkSYAGEkILGPFHk
0 1 K106‑ub kILGPFHkRFsCIIG
0 3 S109‑p GPFHkRFsCIIGPNG
0 7 S143‑p KIRSKKLsVLIHNsD
0 1 S149‑p LsVLIHNsDEHKDIQ
0 54 Y175‑p IDKEGDDyEVIPNSN
0 1 T188‑p SNFYVSRtACRDNTS
0 12 Y197‑p CRDNTSVyHIsGkkK
0 1 S200‑p NTSVyHIsGkkKTFk
0 8 K202‑ub SVyHIsGkkKTFkDV
0 1 K203‑ub VyHIsGkkKTFkDVG
0 22 K207‑ub sGkkKTFkDVGNLLR
0 1 K207‑sc sGkkKTFkDVGNLLR
0 1 K241‑ub QIAMMKPkGQTEHDE
0 1 K268‑ac GRLNEPIkVLCRRVE
0 1 K268‑ub GRLNEPIkVLCRRVE
0 1 K341‑ub IAEMETQkEkIHEDt
0 1 K343‑ub EMETQkEkIHEDtkE
0 1 T348‑p kEkIHEDtkEINEks
0 2 K349‑ac EkIHEDtkEINEksN
0 1 K354‑ac DtkEINEksNILSNE
0 2 S355‑p tkEINEksNILSNEM
0 2 K363‑ac NILSNEMkAKNKDVK
0 1 K374 KDVKDTEKKLNKITk
0 1 K378 DTEKKLNKITkFIEE
0 1 K381‑ac KKLNKITkFIEENKE
0 1 K389‑ub FIEENKEkFTQLDLE
0 1 K413‑ub HATSKAKkLEkQLQK
0 1 K416‑ac SKAKkLEkQLQKDKE
0 1 S489‑p EKELMGFsKSVNEAR
0 1 S531‑p KEALIAAsEtLKERK
0 1 T533‑p ALIAAsEtLKERKAA
0 2 K573‑ac TQEETNFksLVHDLF
0 1 S574‑p QEETNFksLVHDLFQ
0 1 S588‑p QKVEEAKssLAMNRs
0 1 S589‑p KVEEAKssLAMNRsR
0 1 S595‑p ssLAMNRsRGkVLDA
0 1 K598‑ac AMNRsRGkVLDAIIQ
0 1 K598‑ub AMNRsRGkVLDAIIQ
0 3 K607‑ac LDAIIQEkkSGRIPG
0 2 K607‑ub LDAIIQEkkSGRIPG
0 1 K608‑ac DAIIQEkkSGRIPGI
0 1 Y616‑p SGRIPGIyGRLGDLG
0 1 A675 FIGLDKMAVWAkKMt
0 1 K679‑ac DKMAVWAkKMtEIQt
0 1 T682‑p AVWAkKMtEIQtPEN
0 1 T686‑p kKMtEIQtPENTPRL
0 1 K698‑ub PRLFDLVkVKDEKIR
0 11 Y709‑p EKIRQAFyFALRDTL
0 1 T739‑p DRRWRVVtLQGQIIE
0 1 T822‑p RNTLEKFtASIQRLI
0 1 K946 DSVLRTEKEIKDTEK
0 5 S982‑p NTNAAEEsLPEIQkE
0 1 K988‑ub EsLPEIQkEHRNLLQ
0 2 K1009‑ac ENEHALQkDALsIKL
0 1 S1013‑p ALQkDALsIKLKLEQ
0 1 S1030‑p GHIAEHNskIKYWHk
0 1 K1031‑ac HIAEHNskIKYWHkE
0 1 K1037‑ac skIKYWHkEISKISL
0 8 S1056‑p DNPIEEIsVLsPEDL
0 2 S1059‑p IEEIsVLsPEDLEAI
0 1 K1098‑ub GAIAEYKkkEELYLQ
0 5 K1099‑ub AIAEYKkkEELYLQR
0 6 K1112‑ub QRVAELDkITyERDS
0 1 Y1115‑p AELDkITyERDSFRQ
0 1 K1145‑ub GFYIITNkLKENYQM
0 4 K1187‑ub PPKKSWKkIFNLSGG
0 1 Y1266‑p SDRLIGIykTYNITk
0 4 K1267‑ub DRLIGIykTYNITkS
0 8 K1273‑ub ykTYNITkSVAVNPk
0 2 K1280‑ub kSVAVNPkEIASkGL
0 6 K1285‑ub NPkEIASkGLC____
  SMC4 iso2  
S22 EEGPPPPSPDGASSD
S27 PPSPDGASSDAEPEP
S28 PSPDGASSDAEPEPP
S36 DAEPEPPSGRTESPA
T39 PEPPSGRTESPATAA
S41 PPSGRTESPATAAET
T44 GRTESPATAAETASE
T48 SPATAAETASEELDN
S50 ATAAETASEELDNRS
T85 GAPRLMITHIVNQNF
K93 HIVNQNFKSYAGEKI
K99 FKSYAGEKILGPFHK
K106 KILGPFHKRFSCIIG
S109 GPFHKRFSCIIGPNG
S143 KIRSKKLSVLIHNSD
S149 LSVLIHNSDEHKDIQ
Y175 IDKEGDDYEVIPNSN
T188 SNFYVSRTACRDNTS
Y197 CRDNTSVYHISGKKK
S200 NTSVYHISGKKKTFK
K202 SVYHISGKKKTFKDV
K203 VYHISGKKKTFKDVG
K207 SGKKKTFKDVGNLLR
K207 SGKKKTFKDVGNLLR
K241 QIAMMKPKGQTEHDE
K268 GRLNEPIKVLCRRVE
K268 GRLNEPIKVLCRRVE
K341 IAEMETQKEKIHEDT
K343 EMETQKEKIHEDTKE
T348 KEKIHEDTKEINEKS
K349 EKIHEDTKEINEKSN
K354 DTKEINEKSNILSNE
S355 TKEINEKSNILSNEM
K363 NILSNEMKAKNKDVK
K374 KDVKDTEKKLNKITK
K378 DTEKKLNKITKFIEE
K381 KKLNKITKFIEENKE
K389 FIEENKEKFTQLDLE
K413 HATSKAKKLEKQLQK
K416 SKAKKLEKQLQKDKE
S489 EKELMGFSKSVNEAR
S531 KEALIAASETLKERK
T533 ALIAASETLKERKAA
K573 TQEETNFKSLVHDLF
S574 QEETNFKSLVHDLFQ
S588 QKVEEAKSSLAMNRS
S589 KVEEAKSSLAMNRSR
S595 SSLAMNRSRGKVLDA
K598 AMNRSRGKVLDAIIQ
K598 AMNRSRGKVLDAIIQ
K607 LDAIIQEKKSGRIPG
K607 LDAIIQEKKSGRIPG
K608 DAIIQEKKSGRIPGI
Y616 SGRIPGIYGRLGDLG
A675 FIGLDKMAVWAKKMT
K679 DKMAVWAKKMTEIQT
T682 AVWAKKMTEIQTPEN
T686 KKMTEIQTPENTPRL
K698 PRLFDLVKVKDEKIR
Y709 EKIRQAFYFALRDTL
T739 DRRWRVVTLQGQIIE
T822 RNTLEKFTASIQRLI
K946 DSVLRTEKEIKDTEK
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S998 DNPIEEISVLSPEDL
S1001 IEEISVLSPEDLEAI
K1040 GAIAEYKKKEELYLQ
K1041 AIAEYKKKEELYLQR
K1054 QRVAELDKITYERDS
Y1057 AELDKITYERDSFRQ
K1087 GFYIITNKLKENYQM
K1129 PPKKSWKKIFNLSGG
Y1208 SDRLIGIYKTYNITK
K1209 DRLIGIYKTYNITKS
K1215 YKTYNITKSVAVNPK
K1222 KSVAVNPKEIASKGL
K1227 NPKEIASKGLC____
  mouse

 
S21 QEEGPPPSQDGAHsD
H26 PPSQDGAHsDEEMEQ
S27‑p PSQDGAHsDEEMEQP
A35 DEEMEQPAGEAESAA
A38 MEQPAGEAESAAPAK
S40 QPAGEAESAAPAKPP
A42 AGEAESAAPAKPPGE
P46 ESAAPAKPPGEELDN
G48 AAPAKPPGEELDNRS
T83 GAPRLMITHIVNQNF
K91 HIVNQNFKSYAGEKV
K97 FKSYAGEKVLGPFHK
K104 KVLGPFHKRFSCIIG
S107 GPFHKRFSCIIGPNG
S141 KIRSKKLSVLIHNSD
S147 LSVLIHNSDEHKDIQ
Y173 IDKEGDDYEVLPNSN
T186 SNFYVSRTAYRDSTS
Y195 YRDSTSVYHISGKKK
S198 STSVYHISGKKKTFK
K200 SVYHISGKKKTFKDV
K201 VYHISGKKKTFKDVG
K205 SGKKKTFKDVGNLLR
K205 SGKKKTFKDVGNLLR
K239 QIAMMKPKGQTEHDE
K266 GRLNEPIKVLCRRVE
K266 GRLNEPIKVLCRRVE
K339 IAEITTQKEKIHEDT
K341 EITTQKEKIHEDTKE
T346 KEKIHEDTKEITEKS
K347 EKIHEDTKEITEKSN
K352 DTKEITEKSNVLSNE
S353 TKEITEKSNVLSNEM
K361 NVLSNEMKAKNSAVK
K372‑ac SAVKDVEkKLNkVTK
K376‑ac DVEkKLNkVTKFIEQ
K379 kKLNkVTKFIEQNKE
K387 FIEQNKEKFTQLDLE
K411 HATSKAKKLEKQLQK
K414 SKAKKLEKQLQKDKE
N487 EKELMGFNKSVNEAR
S529 KEALITASETLKERK
T531 ALITASETLKERKAA
K571 TQEEINLKSLVHDLF
S572 QEEINLKSLVHDLFQ
S586 QKVEEAKSSLAMNRS
S587 KVEEAKSSLAMNRSR
S593 SSLAMNRSRGKVLDA
K596 AMNRSRGKVLDAIIQ
K596 AMNRSRGKVLDAIIQ
K605 LDAIIQEKKSGRIPG
K605 LDAIIQEKKSGRIPG
K606 DAIIQEKKSGRIPGI
Y614 SGRIPGIYGRLGDLG
T673‑p FIGLDKMtVWAKKMS
K677 DKMtVWAKKMSKIQT
S680 tVWAKKMSKIQTPEN
T684 KKMSKIQTPENTPRL
K696 PRLFDLVKVKNEEIR
Y707 EEIRQAFYFALRDTL
T737 DRRWRVVTLQGQIIE
A820 RNTLEKFAASIQGLS
K944 DSVCRTEKEIKDTEK
S980 NTKTAETSLPEIQKE
K986 TSLPEIQKEHRNLLQ
K1007 ENEHALQKDALSIKL
S1011 ALQKDALSIKLKLEQ
S1028 GHISEHNSKIKYWQK
K1029 HISEHNSKIKYWQKE
K1035 SKIKYWQKEISKIKL
A1054 DNPVETVAVLSQEEL
S1057 VETVAVLSQEELEAI
K1096 GAIAEYKKKEDLYLQ
K1097 AIAEYKKKEDLYLQR
K1110 QRVAELDKITSERDN
S1113 AELDKITSERDNFRQ
K1143 GFYVITNKLKENYQM
K1185‑ub PPKKSWKkIFNLSGG
Y1264 SDRLIGIYKTYNSTK
K1265 DRLIGIYKTYNSTKS
K1271 YKTYNSTKSVAVNPK
K1278 KSVAVNPKQIASKGL
K1283 NPKQIASKGLC____
  rat

 
S21 QEEGPPPSEDGALsE
L26 PPSEDGALsEGEKEQ
S27‑p PSEDGALsEGEKEQP
D35 EGEKEQPDCEVDSAA
V38 KEQPDCEVDSAAAAE
S40 QPDCEVDSAAAAETP
A42 DCEVDSAAAAETPGE
T46 DSAAAAETPGEELDS
G48 AAAAETPGEELDSRS
T83 GAPRLMITHIVNQNF
K91 HIVNQNFKSYAGEKI
K97 FKSYAGEKILGPFHK
K104 KILGPFHKRFSCIIG
S107 GPFHKRFSCIIGPNG
S141 KIRSKKLSVLIHNSD
S147 LSVLIHNSDEHTDIQ
Y173 IDKEGDDYDVLPNSN
T186 SNFYVSRTAYRDNTS
Y195 YRDNTSVYHISGKKR
S198 NTSVYHISGKKRTFK
K200 SVYHISGKKRTFKDV
K201 VYHISGKKRTFKDVG
K205 SGKKRTFKDVGNLLR
K205 SGKKRTFKDVGNLLR
K239 QIAMMKPKGQTEHDE
K266 GRLNEPIKVLCRRVE
K266 GRLNEPIKVLCRRVE
K339 IAEMKTQKEKIHEDT
K341 EMKTQKEKIHEDTKE
T346 KEKIHEDTKEITEKS
K347 EKIHEDTKEITEKSN
K352 DTKEITEKSNVLSNE
S353 TKEITEKSNVLSNEM
K361 NVLSNEMKAKNSAVK
K372 SAVKDIEKKLNKVTK
K376 DIEKKLNKVTKFIEQ
K379 KKLNKVTKFIEQNKE
K387 FIEQNKEKFTQLDLE
K411 HATSKAKKLEKQLQK
K414 SKAKKLEKQLQKDKE
N487 EKELMGFNKSVNEAR
S529 KDALITASETLKERK
T531 ALITASETLKERKAA
K571 TQEEINLKSLVHDLF
S572 QEEINLKSLVHDLFQ
S586 QKVEEAKSSLATNRS
S587 KVEEAKSSLATNRSR
S593 SSLATNRSRGKVLDA
K596 ATNRSRGKVLDAIIQ
K596 ATNRSRGKVLDAIIQ
K605 LDAIIQEKKSGRIPG
K605 LDAIIQEKKSGRIPG
K606 DAIIQEKKSGRIPGI
Y614 SGRIPGIYGRLGDLG
A673 FIGLDKMAVWAQKMN
Q677 DKMAVWAQKMNKIQT
N680 AVWAQKMNKIQTPEN
T684 QKMNKIQTPENTPRL
K696 PRLFDLVKVKNEEIR
Y707 EEIRQAFYFALRDTL
T737 DRRWRVVTLQGQIIE
T820 RNTLEKFTASIQGLS
K944‑ac DSVCRTEkEIKDTEK
S980 NTKDAEKSLPEIQKE
K986 KSLPEIQKEHRALLQ
K1007 DNEHALQKDALSIKL
S1011 ALQKDALSIKLKLEQ
S1028 GHISEHNSKIKYWQK
K1029 HISEHNSKIKYWQKE
K1035 SKIKYWQKEISKIKL
S1054 DNPVETVSVLSQEDL
S1057 VETVSVLSQEDLEAI
K1096 GAIAEYKKKEELYLQ
K1097 AIAEYKKKEELYLQR
K1110 QRVGELDKITSERDN
S1113 GELDKITSERDNFRQ
K1143 GFYVITNKLKENYQM
K1185 PPKKSWKKIFNLSGG
Y1264 SDRLIGIYKTYNITK
K1265 DRLIGIYKTYNITKS
K1271 YKTYNITKSVAVNPK
K1278 KSVAVNPKEIASKGL
K1283 NPKEIASKGLC____
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.