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Protein Page:
SGK3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SGK3 Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes. Interacts with GSK3B and FLII. Interacts with PDPK1 in a phosphorylation-dependent manner. Induced by estrogen/ER in breast cancer cells. Expressed in most tissues with highest levels in pancreas, kidney liver, heart and brain and lower levels in lung, placenta and skeletal muscle. Expression is higher in ER- positive breast tumors than ER-negative breast tumors. Two specific sites, one in the kinase domain (Thr-320) and the other in the C-terminal regulatory region (Ser- 486), need to be phosphorylated for its full activation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, AGC; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); AGC group; SGK family
Chromosomal Location of Human Ortholog: 8q12
Cellular Component: cytoplasmic membrane-bound vesicle; cytosol
Molecular Function: calcium channel regulator activity; chloride channel regulator activity; potassium channel regulator activity; protein binding; protein kinase activity; sodium channel regulator activity
Biological Process: cellular sodium ion homeostasis; peptidyl-serine phosphorylation; positive regulation of transporter activity; protein amino acid phosphorylation; regulation of apoptosis; regulation of cell growth; regulation of cell migration; regulation of cell proliferation; regulation of transcription factor activity; response to stress
Reference #:  Q96BR1 (UniProtKB)
Alt. Names/Synonyms: CISK; cytokine-independent survival kinase; DKFZp781N0293; Serine/threonine-protein kinase Sgk3; serum/glucocorticoid regulated kinase 3; serum/glucocorticoid regulated kinase family, member 3; serum/glucocorticoid regulated kinase-like; Serum/glucocorticoid-regulated kinase 3; Serum/glucocorticoid-regulated kinase-like; SGK2; SGK3; SGKL
Gene Symbols: SGK3
Molecular weight: 57,108 Da
Basal Isoelectric point: 6.45  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SGK3

Protein Structure Not Found.
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Sites Implicated In
enzymatic activity, induced: S486‑p
molecular association, regulation: S486‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K75‑m2 MALKIPAkRIFGDNF
0 15 S126‑p MDSPKHQsDPsEDED
0 17 S129‑p PKHQsDPsEDEDERS
0 1 T143 SSQKLHSTSQNINLG
0 1 S144 SQKLHSTSQNINLGP
0 1 Y188‑p RKLDGKFyAVKVLQK
0 1 S315‑p CKEGIAIsDTtTtFC
0 1 T318‑p GIAIsDTtTtFCGtP
3 2 T320‑p AIsDTtTtFCGtPEY
0 1 T324‑p TtTtFCGtPEYLAPE
4 0 S486‑p DDAFVGFsYAPPSED
5642 : Phospho-SGK3 (Thr320) (D30E6) Rabbit mAb
  mouse

 
K75 MALKIPAKRIFGDNF
S126‑p MDSPRHQsDPsEDED
S129‑p PRHQsDPsEDEDERS
T143‑p STSKPHStsRNINLG
S144‑p TSKPHStsRNINLGP
Y188 RKLDGKFYAVKVLQK
S315 CKEGIAISDTTTTFC
T318 GIAISDTTTTFCGTP
T320 AISDTTTTFCGTPEY
T324 TTTTFCGTPEYLAPE
S486‑p DDAFVGFsYAPPSED
5642 : Phospho-SGK3 (Thr320) (D30E6) Rabbit mAb
  rat

 
K75 MALKIPAKRIFGDNF
S126‑p MDSPRHQsDPsEDED
S129‑p PRHQsDPsEDEDERS
T143 STPKPHSTSRNINLG
S144 TPKPHSTSRNINLGP
Y188 RKLDGKFYAVKVLQK
S315 CKEGIAISDTTTTFC
T318 GIAISDTTTTFCGTP
T320 AISDTTTTFCGTPEY
T324 TTTTFCGTPEYLAPE
S486 DDAFVGFSYAPPSED
5642 : Phospho-SGK3 (Thr320) (D30E6) Rabbit mAb
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