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Protein Page:
MECP2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MECP2 Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Interacts with FNBP3. Interacts with CDKL5. Present in all adult somatic tissues tested. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: cytosol; extracellular space; heterochromatin; mitochondrion; nuclear chromatin; nucleus; protein complex
Molecular Function: chromatin DNA binding; DNA binding; double-stranded methylated DNA binding; four-way junction DNA binding; histone deacetylase binding; methyl-CpG binding; mRNA binding; protein binding; protein domain specific binding; protein N-terminus binding; siRNA binding; transcription corepressor activity; transcription factor activity; transcription factor binding; unmethylated CpG binding
Biological Process: adult locomotory behavior; behavioral fear response; cardiolipin metabolic process; catecholamine secretion; cerebellum development; chromatin silencing; dendrite development; genetic imprinting; glucocorticoid metabolic process; glutamine metabolic process; heart development; histone acetylation; histone methylation; inositol metabolic process; locomotory behavior; long-term memory; mitochondrial electron transport, ubiquinol to cytochrome c; negative regulation of astrocyte differentiation; negative regulation of histone acetylation; negative regulation of histone methylation; negative regulation of neuron apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neurological control of breathing; neuron maturation; pathogenesis; phosphatidylcholine metabolic process; positive regulation of cell proliferation; positive regulation of synaptogenesis; positive regulation of transcription, DNA-dependent; post-embryonic development; proprioception; protein localization; regulation of excitatory postsynaptic membrane potential; regulation of systemic arterial blood pressure by neurological process; respiratory gaseous exchange; response to estradiol stimulus; response to hypoxia; response to ionizing radiation; response to lead ion; response to radiation; sensory perception of pain; social behavior; startle response; synaptogenesis; transcription, DNA-dependent; ventricular system development; visual learning
Disease: Angelman Syndrome; Autism, Susceptibility To, X-linked 3; Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations; Lubs X-linked Mental Retardation Syndrome; Mental Retardation, X-linked, Syndromic 13; Rett Syndrome
Reference #:  P51608 (UniProtKB)
Alt. Names/Synonyms: AUTSX3; DKFZp686A24160; MeCp-2 protein; MECP2; methyl CpG binding protein 2 (Rett syndrome); Methyl-CpG-binding protein 2; MRX16; MRX79; MRXS13; MRXSL; PPMX; RS; RTS; RTT
Gene Symbols: MECP2
Molecular weight: 52,441 Da
Basal Isoelectric point: 9.95  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MECP2

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: S80‑p
transcription, altered: S80‑p, S229‑p
molecular association, regulation: S80‑p, S229‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 5 S13‑p LGLREEKsEDQDLQG
0 1 K42 KKEEKEGKHEPVQPS
0 2 S53‑p VQPSAHHsAEPAEAG
0 1 S68 KAETSEGSGSAPAVP
0 1 S70 ETSEGSGSAPAVPEA
0 9 S78‑p APAVPEAsAsPKQRR
6 52 S80‑p AVPEAsAsPKQRRsI
1 1 S86‑p AsPKQRRsIIRDRGP
0 3 S116‑p KQRKSGRsAGkyDVY
0 1 K119‑m2 KSGRsAGkyDVYLIN
1 0 Y120‑p SGRsAGkyDVYLINP
0 1 K130‑ub YLINPQGkAFRSKVE
0 1 T148 YFEKVGDTsLDPNDF
0 4 S149‑p FEKVGDTsLDPNDFD
0 1 T160 NDFDFTVTGRGSPsR
0 5 R162 FDFTVTGRGSPsRRE
0 2 S164 FTVTGRGSPsRREQK
0 3 S166‑p VTGRGSPsRREQKPP
0 1 R167 TGRGSPsRREQKPPK
0 1 S178 KPPKKPKSPKAPGtG
0 1 T184‑p KSPKAPGtGRGRGRP
0 1 K210‑m2 TSEGVQVkRVLEKsP
0 9 S216‑p VkRVLEKsPGkLLVK
0 2 K219‑ac VLEKsPGkLLVKMPF
1 0 K223 sPGkLLVKMPFQtsP
0 2 T228‑p LVKMPFQtsPGGKAE
2 21 S229‑p VKMPFQtsPGGKAEG
1 5 S274‑p KRGRKPGsVVAAAAA
0 1 K285‑ac AAAAEAKkKAVKESS
1 1 S292 kKAVKESSIRSVQET
0 2 S295 VKESSIRSVQETVLP
1 0 T308 LPIKKRKTREtVsIE
0 3 T311‑p KKRKTREtVsIEVKE
0 3 S313‑p RKTREtVsIEVKEVV
0 2 K321 IEVKEVVKPLLVSTL
0 1 S332‑p VSTLGEKsGKGLKTC
0 2 S341 KGLKTCKSPGRKSKE
0 1 S349‑p PGRKSKEsSPKGRsS
0 2 S355‑p EsSPKGRsSsAssPP
0 2 S357‑p SPKGRsSsAssPPKK
0 2 S359‑p KGRsSsAssPPKKEH
0 4 S360‑p GRsSsAssPPKKEHH
0 1 S395‑p PPPPEPEsSEDPTSP
0 1 S401 EsSEDPTSPPEPQDL
7 8 S423‑p EKMPRGGsLEsDGCP
1 5 S426‑p PRGGsLEsDGCPKEP
1 1 T436 CPKEPAKTQPAVATA
1 0 T442 KTQPAVATAATAAEk
0 3 K449‑ac TAATAAEkYKHRGEG
0 1 T479‑p EEPVDSRtPVTERVs
0 2 S486‑p tPVTERVs_______
  MECP2 iso2  
S10 AAAAAAPSGGGGGGE
S25‑p EERLEEKsEDQDLQG
K54 KKEEKEGKHEPVQPS
S65 VQPSAHHSAEPAEAG
S80 KAETSEGSGSAPAVP
S82 ETSEGSGSAPAVPEA
S90 APAVPEASASPKQRR
S92 AVPEASASPKQRRSI
S98 ASPKQRRSIIRDRGP
S128 KQRKSGRSAGKYDVY
K131 KSGRSAGKYDVYLIN
Y132 SGRSAGKYDVYLINP
K142 YLINPQGKAFRSKVE
T160 YFEKVGDTSLDPNDF
S161 FEKVGDTSLDPNDFD
T172 NDFDFTVTGRGSPSR
R174 FDFTVTGRGSPSRRE
S176 FTVTGRGSPSRREQK
S178 VTGRGSPSRREQKPP
R179 TGRGSPSRREQKPPK
S190 KPPKKPKSPKAPGTG
T196 KSPKAPGTGRGRGRP
K222 TSEGVQVKRVLEKSP
S228 VKRVLEKSPGKLLVK
K231 VLEKSPGKLLVKMPF
K235 SPGKLLVKMPFQTSP
T240 LVKMPFQTSPGGKAE
S241 VKMPFQTSPGGKAEG
S286 KRGRKPGSVVAAAAA
K297 AAAAEAKKKAVKESS
S304 KKAVKESSIRSVQET
S307 VKESSIRSVQETVLP
T320 LPIKKRKTRETVSIE
T323 KKRKTRETVSIEVKE
S325 RKTRETVSIEVKEVV
K333 IEVKEVVKPLLVSTL
S344 VSTLGEKSGKGLKTC
S353 KGLKTCKSPGRKSKE
S361 PGRKSKESSPKGRSS
S367 ESSPKGRSSSASSPP
S369 SPKGRSSSASSPPKK
S371 KGRSSSASSPPKKEH
S372 GRSSSASSPPKKEHH
S407 PPPPEPESSEDPTSP
S413 ESSEDPTSPPEPQDL
S435 EKMPRGGSLESDGCP
S438 PRGGSLESDGCPKEP
T448 CPKEPAKTQPAVATA
T454 KTQPAVATAATAAEK
K461 TAATAAEKYKHRGEG
T491 EEPVDSRTPVTERVS
S498 TPVTERVS_______
  mouse

► Hide Isoforms
 
- gap
S13‑p LGLREEKsEDQDLQG
K42 KKEDKEGKHEPLQPS
S53 LQPSAHHSAEPAEAG
S68‑p KAETSESsGsAPAVP
S70‑p ETSESsGsAPAVPEA
S78‑p APAVPEAsAsPKQRR
S80‑p AVPEAsAsPKQRRsI
S86‑p AsPKQRRsIIRDRGP
S116 KQRKSGRSAGKyDVY
K119 KSGRSAGKyDVYLIN
Y120‑p SGRSAGKyDVYLINP
K130 YLINPQGKAFRSKVE
T148‑p YFEKVGDtsLDPNDF
S149‑p FEKVGDtsLDPNDFD
T160‑p NDFDFTVtGrGsPsr
R162‑m1 FDFTVtGrGsPsrRE
S164‑p FTVtGrGsPsrREQK
S166‑p VtGrGsPsrREQKPP
R167‑m1 tGrGsPsrREQKPPK
S178‑p KPPKKPKsPKAPGtG
T184‑p KsPKAPGtGRGRGRP
K210 ASEGVQVKRVLEKsP
S216‑p VKRVLEKsPGKLVVk
K219 VLEKsPGKLVVkMPF
K223‑sm sPGKLVVkMPFQAsP
A228 VVkMPFQAsPGGKGE
S229‑p VkMPFQAsPGGKGEG
S274‑p KRGRKPGsVVAAAAA
K285 AAAAEAKKKAVKESs
S292‑p KKAVKESsIRsVHET
S295‑p VKESsIRsVHETVLP
T308‑p LPIKKRKtREtVsIE
T311‑p KKRKtREtVsIEVKE
S313‑p RKtREtVsIEVKEVV
K321‑ac IEVKEVVkPLLVSTL
S332 VSTLGEKSGKGLKTC
S341‑p KGLKTCKsPGRKSKE
S349 PGRKSKESSPKGRSS
S355 ESSPKGRSSSASsPP
S357 SPKGRSSSASsPPKK
S359 KGRSSSASsPPKKEH
S360‑p GRSSSASsPPKKEHH
S393 PPPPEPESSEDPIsP
S399‑p ESSEDPIsPPEPQDL
S421‑p EKMPRGGsLEsDGCP
S424‑p PRGGsLEsDGCPKEP
T434‑gl CPKEPAKtQPMVATT
T440 KtQPMVATTTTVAEK
K447 TTTTVAEKYKHRGEG
T477 EEPVDSRTPVTERVs
S484‑p TPVTERVs_______
  MECP2 iso2  
S15‑p AAAAAAPsGGGGGGE
S30 EERLEEKSEDQDLQG
K59 KKEDKEGKHEPLQPS
S70 LQPSAHHSAEPAEAG
S85 KAETSESSGSAPAVP
S87 ETSESSGSAPAVPEA
S95 APAVPEASASPKQRR
S97 AVPEASASPKQRRSI
S103 ASPKQRRSIIRDRGP
S133 KQRKSGRSAGKYDVY
K136 KSGRSAGKYDVYLIN
Y137 SGRSAGKYDVYLINP
K147 YLINPQGKAFRSKVE
T165 YFEKVGDTSLDPNDF
S166 FEKVGDTSLDPNDFD
T177 NDFDFTVTGRGSPSR
R179 FDFTVTGRGSPSRRE
S181 FTVTGRGSPSRREQK
S183 VTGRGSPSRREQKPP
R184 TGRGSPSRREQKPPK
S195 KPPKKPKSPKAPGTG
T201 KSPKAPGTGRGRGRP
K227 ASEGVQVKRVLEKSP
S233 VKRVLEKSPGKLVVK
K236 VLEKSPGKLVVKMPF
K240 SPGKLVVKMPFQASP
A245 VVKMPFQASPGGKGE
S246 VKMPFQASPGGKGEG
S291 KRGRKPGSVVAAAAA
K302 AAAAEAKKKAVKESS
S309 KKAVKESSIRSVHET
S312 VKESSIRSVHETVLP
T325 LPIKKRKTRETVSIE
T328 KKRKTRETVSIEVKE
S330 RKTRETVSIEVKEVV
K338 IEVKEVVKPLLVSTL
S349 VSTLGEKSGKGLKTC
S358 KGLKTCKSPGRKSKE
S366 PGRKSKESSPKGRSS
S372 ESSPKGRSSSASSPP
S374 SPKGRSSSASSPPKK
S376 KGRSSSASSPPKKEH
S377 GRSSSASSPPKKEHH
S410 PPPPEPESSEDPISP
S416 ESSEDPISPPEPQDL
S438 EKMPRGGSLESDGCP
S441 PRGGSLESDGCPKEP
T451 CPKEPAKTQPMVATT
T457 KTQPMVATTTTVAEK
K464 TTTTVAEKYKHRGEG
T494 EEPVDSRTPVTERVS
S501 TPVTERVS_______
  rat

 
- gap
S13‑p LGLRKEKsEDQDLQG
K42‑ac KKEDKEGkHEPLQPS
S53 LQPSAHHSAEPAEAG
S68 KAETSESSGSAPAVP
S70 ETSESSGSAPAVPEA
S78‑p APAVPEAsAsPKQRR
S80‑p AVPEAsAsPKQRRSI
S86 AsPKQRRSIIRDRGP
S116 KQRKSGRSAGKYDVY
K119 KSGRSAGKYDVYLIN
Y120 SGRSAGKYDVYLINP
K130 YLINPQGKAFRSKVE
T148 YFEKVGDTSLDPNDF
S149 FEKVGDTSLDPNDFD
T160 NDFDFTVTGRGSPSR
R162 FDFTVTGRGSPSRRE
S164 FTVTGRGSPSRREQK
S166 VTGRGSPSRREQKPP
R167 TGRGSPSRREQKPPK
S178 KPPKKPKSPKAPGTG
T184 KSPKAPGTGRGRGRP
K210 ASEGVQVKRVLEKsP
S216‑p VKRVLEKsPGkLLVK
K219‑ac VLEKsPGkLLVKMPF
K223 sPGkLLVKMPFQAsP
A228 LVKMPFQAsPGGKGE
S229‑p VKMPFQAsPGGKGEG
S274 KRGRKPGSVVAAAAA
K285 AAAAEAKKKAVKESs
S292‑p KKAVKESsIRSVQET
S295 VKESsIRSVQETVLP
T308 LPIKKRKTRETVSIE
T311 KKRKTRETVSIEVKE
S313 RKTRETVSIEVKEVV
K321‑ac IEVKEVVkPLLVSTL
S332 VSTLGEKSGKGLKTC
S341 KGLKTCKSPGRKSKE
S349 PGRKSKESSPKGRSS
S355 ESSPKGRSSSASSPP
S357 SPKGRSSSASSPPKK
S359 KGRSSSASSPPKKEH
S360 GRSSSASSPPKKEHH
S393 PPPPEPQSSEDPIsP
S399‑p QSSEDPIsPPEPQDL
S421‑p EKMPRAGsLESDGCP
S424 PRAGsLESDGCPKEP
T434‑gl CPKEPAKtQPMVAAA
T443‑gl PMVAAAAtTTTTTTT
K455 TTTTVAEKYKHRGEG
T485 EEPVDSRTPVTERVS
S492 TPVTERVS_______
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